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CCR5 (6-20) Rabbit Polyclonal Antibody

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SKU
AP05821PU-N
CCR5 (6-20) rabbit polyclonal antibody, Purified
Size:
100 ug
Conjugation:
Unconjugated
  $705.00
5 Days*
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View other "CCR5 or NP_000570.1" antibodies

Specifications
Specifications
Product Data
Application IHC, IP, WB
Recommended Dilution Western blot: 1:1000.
Immunohistochemistry on paraffin sections: 20 µg/ml; This product requires antigen retrieval using heat treatment prior to staining of paraffin sections; Sodium citrate buffer pH6.0 is recommended for this purpose.
Reactivity Human
Antibody Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen Peptide corresponding to amino acids 6 to 20 of human CCR5.
Specificity This antibody recognises the N-terminal region of the chemokine receptor CCR5, also known as CD195. CCR5 is a receptor for the beta chemokines RANTES, MIP-1alpha and MIP-1beta.
Buffer Phosphate buffered saline containing 0.02% Sodium Azide
State: Purified
State: Liquid purified IgG
Concentration lot specific
Conjugation Unconjugated
Storage Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Stability Shelf life: one year from despatch.
Shipping Blue Ice
Gene Name C-C motif chemokine receptor 5 (gene/pseudogene)
Database Link
Background The CC chemokine receptor 5 (CCR5) is a member of the CC-chemokine receptor family, and has the characteristic structure of a 7 transmembrane G protein-coupled receptor (GPCR). CCR5 regulates trafficking and effector functions of memory/effector Th1 cells, macrophages, NK cells, and immature dendritic cells. CCR5 and its ligands play an important role in viral pathogenesis. CCR5 represents the co-receptor for macrophage (M) and dual (T cell and M)-tropic immunodeficiency viruses. Together with the CD4 binding receptor, CCR5 plays a critical role in HIV entry into the target cells. Moreover, the CCR5 ligands macrophage inflammatory protein (MIP)-1 alpha, MIP-1 beta and RANTES act as endogenous inhibitors of HIV infection, making both CCR5 and its chemokine ligands attractive therapeutic targets for HIV infection. Recent studies have also highlighted the role of CCR5 in a variety of other human diseases, ranging from infectious and inflammatory diseases to cancer.
Synonyms C-C chemokine receptor type 5, C-C CKR-5, CC-CKR-5, CCR-5, CMKBR5, CHEMR13
Reference Data
Protein Categories Allergies and autoimmune diseases, CD Markers, Chemokines, Diabetes, GPCR, Membrane Proteins
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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