DLL4 Rabbit Polyclonal Antibody
Specifications
| Product Data | |
| Application | ELISA, IHC, WB |
|---|---|
| Recommended Dilution | Immunohistochemistry on paraffin sections: 5 - 15µg/ml. ELISA: 1:3000 - 1:15000. Western Blot: 1:300 - 1:1500; detects a band of approximately 74kDa in pancreatic cell lysates. |
| Reactivity | Human, Monkey, Mouse, Rat |
| Antibody Host | Rabbit |
| Isotype | IgG |
| Clonality | Polyclonal |
| Immunogen | Synthetic peptide corresponding to the internal region of human DLL4. |
| Specificity | This antibody detects human Delta-like ligand 4 (DLL4), also known as Delta-4. |
| Buffer | Phosphate buffered saline pH7.2 containing 0.09% Sodium Azide (NaN3) State: Purified State: Liquid purified IgG |
| Concentration | lot specific |
| Conjugation | Unconjugated |
| Storage | Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. |
| Stability | Shelf life: one year from despatch. |
| Shipping | Blue Ice |
| Gene Name | delta like canonical Notch ligand 4 |
| Database Link | |
| Background | DLL4 is a homologue of the Drosophila delta protein, and functions as a transmembrane bound ligand to the Notch receptor Notch1. DLL4 is expressed in the vasculature and plays a critical role in vascular development. It is induced by vascular endothelial growth factor (VEGF), as a negative feedback regulator to regulate angiogenic sprouting and promote the formation of a differentiated vascular network. DLL4 has been found to be strongly expressed in tumour vessels of clear-cell renal tumours and bladder cancer, and inhibition of DLL4 results in increased vascular proliferation but defective maturation. This in turn leads to a decrease in tumour growth, with no apparent toxicity. |
| Synonyms | Delta 4, Drosophila Delta homolog 4 |
| Reference Data | |
| Protein Categories | Growth Factors, Membrane Proteins |
| Protein Families | Cancer stem cells, Druggable Genome, ES Cell Differentiation/IPS, Stem cell relevant signaling - DSL/Notch pathway, Transmembrane |
| Protein Pathways | Notch signaling pathway |
Reviews
Documents
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| FAQs |
| SDS |
Citations
Loss of CCM3 impairs DLL4-Notch signalling: implication in endothelial angiogenesis and in inherited cerebral cavernous malformations
You, Sandalcioglu, Dammann et al
J Cell Mol Med (2013) 17 (3), 407-18 DOI: 10.1111/jcmm.12022
You, Sandalcioglu, Dammann et al
J Cell Mol Med (2013) 17 (3), 407-18 DOI: 10.1111/jcmm.12022
Cited by 98
AI Summary: In this study, OriGene products including CCM3 (PDCD10) siRNA (SR300363) and DLL4 recombinant protein (TP317802) were used to silence CCM3 expression and to restore DLL4-Notch signalling, respectively, thereby enabling the investigation of their roles in endothelial angiogenesis and cerebral cavernous malformations.
Multiple biomarker tissue arrays: A computational approach to identifying protein-protein interactions in the EGFR/ERK signalling pathway
Villaamil, Gallego, Valladares-Ayerbes et al
J Mol Signal (2012) 7 (1), 14 DOI: 10.1186/1750-2187-7-14
Villaamil, Gallego, Valladares-Ayerbes et al
J Mol Signal (2012) 7 (1), 14 DOI: 10.1186/1750-2187-7-14
Cited by 1
Showing 1-2 of 2 papers.
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