OGR1 (GPR68) Rabbit Polyclonal Antibody
Specifications
| Product Data | |
| Application | FN, IHC, WB |
|---|---|
| Recommended Dilution | Western Blot: 5-10 µg/ml. Western blot should be visualized using a high sensitivity secondary/substrate system. Neutralization. Immunohistochemistry. Positive Control: OGR1 transfected cell lysate. |
| Reactivity | Human |
| Antibody Host | Rabbit |
| Isotype | IgG |
| Clonality | Polyclonal |
| Immunogen | Recombinant protein derived from Human OGR1 (GPR68) protein |
| Specificity | This antibody recognizes OGR1. |
| Buffer | PBS State: Purified State: Liquid purified IgG fraction Preservative: 0.08% Sodium Azide |
| Concentration | lot specific |
| Purification | Ammonium Sulfate Precipitation |
| Conjugation | Unconjugated |
| Storage | Upon receipt, store undiluted (in aliquots) at -20°C. Avoid repeated freezing and thawing. |
| Stability | Shelf life: one year from despatch. |
| Shipping | Blue Ice |
| Gene Name | G protein-coupled receptor 68 |
| Database Link | |
| Background | OGR1 (originally identified as GPR68) is a high-affinity receptor for sphingosylphosphorylcholine (SPC). SPC is a member of a class of bioactive lipids which regulate cellular functions. These functions include cell proliferation and growth inhibition, smooth muscle contration and wound healing. SPC also stimulated signalling pathways that induce tyrosine phosphorylation, activate MAP kinases and protein kinase C, modify ion channel activity and increase intracellular Ca2+ concentration. OGR1 is expressed in placenta, lung, liver, spleen, testis, small intestine and peripheral blood leukocytes. It is not found in thymus, ovary, colon, skeletal muscle, kidney or pancreas. |
| Synonyms | Sphingosylphosphorylcholine receptor, G-protein coupled receptor 68, GPR12A |
| Reference Data | |
| Protein Categories | GPCR, Membrane Proteins |
Reviews
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Citations
RGS18 acts as a negative regulator of osteoclastogenesis by modulating the acid-sensing OGR1/NFAT signaling pathway
Iwai, Koike, Ohshima et al
J Bone Miner Res (2007) 22 (10), 1612-20 DOI: 10.1359/jbmr.070612
Iwai, Koike, Ohshima et al
J Bone Miner Res (2007) 22 (10), 1612-20 DOI: 10.1359/jbmr.070612
Cited by 56
AI Summary: OriGene products contributed to this study by providing the RGS18-specific short interfering RNA (siRNA) and gene-specific RT-PCR primers, which were used to inhibit RGS18 function and assess its expression during osteoclastogenesis.
Showing 1-1 of 1 papers.
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