VAV2 (SHD Region) Sheep Polyclonal Antibody
Specifications
| Product Data | |
| Application | IP, WB |
|---|---|
| Recommended Dilution | Western Blot: 1:5,000. Immunoprecipitation. |
| Reactivity | Human |
| Antibody Host | Sheep |
| Isotype | IgG |
| Clonality | Polyclonal |
| Immunogen | A his tagged fusion protein Vav-2 corresponding to amino acid sequence |
| Specificity | This antibody reacts to Vav-2 SHD. |
| Buffer | Phosphate buffered saline with 0.08% sodium azide State: Purified State: Liquid purified Ig (0.2 µm sterile filtered) |
| Concentration | lot specific |
| Conjugation | Unconjugated |
| Storage | Store the antibody at -20°C. Avoid repeated freezing and thawing. |
| Stability | Shelf life: one year from despatch |
| Shipping | Blue Ice |
| Gene Name | vav guanine nucleotide exchange factor 2 |
| Database Link | |
| Background | The immunogen used for the anti-human Vav-2 SHD region was a his tagged fusion protein Vav-2 corresponding to amino acid sequence 578 - 878 and having a molecular weight of 100kD. Vav-2 has a molecular weight of 100 kD and shares over a 50% homology at the amino acid and nucleic acid level with Vav. Vav-2 is a ubiquitously expressed structural homolog of the Vav protooncogene that is expressed preferentially in hematopoetic cells. Both proteins are comprised of a Dbl- homology (DH) domain with guanosine nucleotide exchange (GEF) activity exclusively directed towards Rho/Rac GTPases, a pleckstrin homology (PH) domain, a calponin-homology (CH) region, an acidic domain (AD) a zinc finger butterfly motif, two SH3 regions and one SH2 domain. GEF activity of RhoA family G proteins is induced by tyrosine phosphorylation in wild type vav-2, and is constitutively activated in N terminus deleted oncogene forms. Constitutive expression of a Vav-2 oncoprotein may result in morphological alterations including highly enlarged cells in which karyokinesis and cytokinesis frequently are uncoupled. |
| Synonyms | VAV-2 |
| Reference Data | |
| Protein Categories | Growth Factors, Intracellular Proteins |
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.
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