Herpes Virus Type 8 / HHV8 Cyclin Sheep Polyclonal Antibody
Herpes Virus Type 8 / HHV8 Cyclin sheep polyclonal antibody, Purified
Product Datasheet for 'AP05011PU-N'
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Specifications
Product Data | |
Applications | IP, WB |
Recommend Dilution | Immunoblotting: 1-5 µg/ml. Immunoprecipitation: 10-20 µg/ml. |
Reactivity | Human |
Host | Sheep |
Isotype | IgG |
Clonality | Polyclonal |
Immunogen | Inclusion Bodies from E. Coli expressing His-tagged full length Human Cyclin G2 protein. |
Specificity | This antibody recognizes Human Herpes Virus 8 cyclin (HHV8 cyclin). Other species not tested. |
Formulation | PBS State: Purified State: Liquid (0.2µm sterile filtered) purified IgG fraction Preservative: 0.08% Sodium Azide |
Purification | Ammonium Sulfate Precipitation |
Predicted Protein Size | 28.1 kDa |
Background | Human herpervirus-8 (HHV-8) cyclin is a component of the HHV-8 virus particle. HHV8 has been found to be associated with three different diseases observed in AIDS patients; kaposi's sarcoma, primary effusion lymphoma (which is a rare type of non-Hodgkin lymphoma affecting the body cavities) and multicentric Castleman's disease. To date there is much evidence to support a direct role for HHV8 in kaposi's sarcoma. |
Synonyms | HHV-8, KHSV |
Reference Data |
Citations (3)
The use of this Antibodies has been cited in the following citations: |
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Lymphatic dysfunction in transgenic mice expressing KSHV k-cyclin under the control of the VEGFR-3 promoter.
,Sugaya M, Watanabe T, Yang A, Starost MF, Kobayashi H, Atkins AM, Borris DL, Hanan EA, Schimel D, Bryant MA, Roberts N, Skobe M, Staskus KA, Kaldis P, Blauvelt A,
Blood 2015
,PubMed ID 15536152
[HHV8]
|
Inhibiting primary effusion lymphoma by lentiviral vectors encoding short hairpin RNA.
,Godfrey A, Anderson J, Papanastasiou A, Takeuchi Y, Boshoff C,
Blood 2012
,PubMed ID 15572586
[HHV8]
|
KSHV viral cyclin binds to p27KIP1 in primary effusion lymphomas.
,Jdrviluoma A, Koopal S, Rdsdnen S, Mdkeld TP, Ojala PM,
Blood 2004
,PubMed ID 15271792
[HHV8]
|
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