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GSK3 alpha (GSK3A) Rabbit Polyclonal Antibody

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SKU
AP02551PU-S
GSK3 alpha (GSK3A) rabbit polyclonal antibody, Aff - Purified
Size:
50 ul 100 ul
Conjugation:
Unconjugated
  $330.00
2 Weeks*
Bulk/Customize

View other "GSK3A or NP_063937.2" antibodies

Specifications
Specifications
Product Data
Application IF, IHC, WB
Recommended Dilution Western Blot: 1/500-1/1000.
Immunohistochemistry on Paraffin Sections: 1/50-1/100.
Immunofluorescence: 1/100-1/200.
Reactivity Human, Mouse, Rat
Antibody Host Rabbit
Clonality Polyclonal
Immunogen Synthetic non-phosphopeptide derived from human GSK3alpha around the phosphorylation site of serine 21 (T-S-SP-F-A).
Specificity This Antibody detects endogenous levels of total GSK3α protein.
Buffer PBS(without Mg2+ and Ca2+), pH 7.4 containing 150mM NaCl, 0.02% Sodium Azide and 50% Glycerol
State: Aff - Purified
State: Liquid purified IgG fraction
Concentration lot specific
Purification Affinity chromatography
Conjugation Unconjugated
Storage Upon receipt, store undiluted (in aliquots) at -20°C.
Avoid repeated freezing and thawing.
Stability Shelf life: one year from despatch.
Shipping Blue Ice
Gene Name glycogen synthase kinase 3 alpha
Database Link
Background Glycogen synthase kinase 3 alpha belongs to the Ser/Thr family of protein kinases, Cdc2/cdkx subfamily; GSK3 subsubfamily. It is implicated in the hormonal control of several regulatory proteins including glycogen synthase, myb, and the transcription factor c jun. GSK3 phosphorylates glycogen synthase and thereby inactivates it. Insulin stimulates the dephosphorylation of glycogen synthase at the sites phosphorylated by GSK3 and subsequently inhibits GSK3 acutely leading to the stimulation of glycogen synthesis. GSK3 signaling is performed by two isoforms, GSK3 alpha and GSK3 beta. The two isoforms share 97% sequence similarity within their catalytic domains. GSK3 has also been shown to play a role in protein synthesis, cell adhesion, cell proliferation, cell differentiation, microtubule dynamics and cell motility.
Synonyms Glycogen synthase kinase-3 alpha, GSK3A, GSK-3 alpha, Factor A
Reference Data
Protein Categories Enzyme: Kinases, Growth Factors, Intracellular Proteins
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Documents
Resources

file-alt Citations

Drug repurposing studies of PARP inhibitors as a new therapy for inherited retinal degeneration
Sahaboglu, Miranda, Canjuga et al
Cell. Mol. Life Sci. (2019)
AI Summary: In this study, the GSKα antibody (AP02551PU-S) from OriGene Technologies was used to investigate the molecular mechanisms underlying PARP inhibitor-induced protection in a mouse model of inherited retinal degeneration.
Snippet: Primary antibodies were diluted in blocking solution in certain concentrations, such as PAR (1:200, ALX-804- 220-R100 Enzo Life Sciences, Lorrach, Germany), GSKα (1:100;AP02551PU-S, OriGene Technologies, Rockville, USA) and ß catenin (1:100;ab16051, Abcam
Showing 1-1 of 1 papers.
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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