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GJA1 pSer368 Rabbit Polyclonal Antibody

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SKU
AP02508PU-N
GJA1 pSer368 rabbit polyclonal antibody, Aff - Purified
Size:
100 ul 50 ul
Conjugation:
Unconjugated
  $430.00
2 Weeks*
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View other "GJA1 or NP_000156.1" antibodies

Specifications
Specifications
Product Data
Application IHC, WB
Recommended Dilution Western Blot: 1/500~1/1000.
Immunohistochemistry: 1/50~1/100 (Suitable for Paraffin Embedded Sections).
Reactivity Human, Mouse, Rat
Antibody Host Rabbit
Clonality Polyclonal
Immunogen The antiserum was produced against synthesized phosphopeptide derived from human Connexin-43 around the phosphorylation site of serine 367 (R-A-SP-S-R).
Specificity The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide.
The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.This antibody detects endogenous levels of Connexin43 only when phosphorylated at serine 367.
Buffer PBS(without Mg2+ and Ca2+), pH 7.4 containing 150mM NaCl, 0.02% sodium azide and 50% glycerol
State: Aff - Purified
State: Liquid purified IgG fractiion.
Concentration lot specific
Purification Immunoaffinity Chromatography.
Conjugation Unconjugated
Storage Store the antibody (in aliquots) at -20°C.
Avoid repeated freezing and thawing.
Stability Shelf life: one year from despatch.
Shipping Blue Ice
Gene Name gap junction protein alpha 1
Database Link
Background GJA1 is a member of the connexin gene family and a component of gap junctions. Gap junctions are composed of arrays of intercellular channels and provide a route for the diffusion of materials of low molecular weight from cell to cell. GJA1 is the major protein of gap junctions in the heart, and gap junctions are thought to have a crucial role in the synchronized contraction of the heart and in embryonic development. GJA1 is targeted by several protein kinases that regulate myocardial cell cell coupling. A related intronless GJA1 pseudogene, GJA1P, has been mapped to chromosome 5.
Synonyms Gap junction alpha-1 protein, Connexin-43, GJAL
Reference Data
Protein Categories Growth Factors, Membrane Proteins
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Documents
Resources

file-alt Citations

Phosphorylation of extrajunctional Cx43 in ischemic-preconditioned rat hearts
Mühlfeld, Cetegen, Freese et al
J Surg Res (2010) 162 (1), e1-8 DOI: 10.1016/j.jss.2010.02.024
Cited by 6
AI Summary: In this study, OriGene products—specifically, the anti-Connexin 43 antibody (Cat# AP13266PU-N)—were used for immunostaining to detect phosphorylated and dephosphorylated Cx43 in rat heart tissue, enabling the authors to assess the effects of ischemic preconditioning on Cx43 localization and phosphorylation status.
Showing 1-1 of 1 papers.
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