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BCR pTyr177 Rabbit Polyclonal Antibody

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SKU
AP02468PU-N
BCR pTyr177 rabbit polyclonal antibody, Aff - Purified
Size:
100 ul 50 ul
Conjugation:
Unconjugated
  $430.00
2 Weeks*
Bulk/Customize

View other "BCR or NP_004318.3" antibodies

Specifications
Specifications
Product Data
Application IHC, WB
Recommended Dilution Suitable for use in Western blot (1/500-1/1000) and Immunohistochemistry on Paraffin-Embedded Sections (1/50-1/100).
Reactivity Human, Mouse
Antibody Host Rabbit
Clonality Polyclonal
Immunogen The antiserum was produced against synthesized phosphopeptide derived from Human Bcr around the phosphorylation site of Tyrosine 177 (P-F-Yp-V-N).
Specificity This antibody detects endogenous levels of Bcr only when phosphorylated at Tyrosine 177.
Buffer PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02% Sodium Azide and 50% Glycerol
State: Aff - Purified
State: Liquid purified Ig fraction.
Concentration lot specific
Purification Affinity Chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatogramphy using non-phosphopeptide corresponding to the phosphorylation site.
Conjugation Unconjugated
Storage Store the antibody (in aliquots) at -20°C.
Avoid repeated freezing and thawing.
Stability Shelf life: One year from despatch.
Shipping Blue Ice
Gene Name BCR, RhoGEF and GTPase activating protein
Database Link
Background The breakpoint cluster region protein (Bcr) is best know to be involved in genomic translocation with fusion partner Abl (Cbr-Abl) causing chronic myelogenous leukemia (CML). This 160 kDa protein contains a serine/threonine kinase domain, an SH2 binding domain, a GTP/GDP exchange domain and a C-term domain which functions as a GTPase activating protein for p21rac and CDC42. Additionally, Bcr is involved in signal transduction and can down regulate Ras mediated cell signaling.
Synonyms Breakpoint cluster region protein, BCR1, D22S11, NY-REN-26
Note Molecular Weight: 210 kDa
Reference Data
Protein Categories Cancer: Haematopoietic and Lymphoid, Intracellular Proteins
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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