GNAZ Rabbit Polyclonal Antibody

CAT#: AP01358PU-N

GNAZ rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot (WB) analysis of Gz-a antibody (Cat.-No.: AP01358PU-N) in extracts from COS7 cells treated with PMA 125ng/ml 30'.

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  Immunohistochemistry (IHC) analyzes of Gz-a antibody (Cat.-No.: AP01358PU-N) in paraffin-embedded human brain tissue

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: Western Blot: 1/500-1/1000.
  Immunohistochemistry on paraffin sections: 1/50-1/200.
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Clonality: Polyclonal
• Specificity: Gz-α antibody detects endogenous levels of Gz-α protein. (region surrounding Ala12)
• Formulation: Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
  State: Aff - Purified
  State: Liquid purified Ig fraction
• Concentration: 1.0 mg/ml
• Purification: Affinity chromatography
• Conjugation: Unconjugated
• Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Predicted Protein Size: ~ 41 kDa
• Gene Name: G protein subunit alpha z
• Database Link:
  Entrez Gene 14687 MouseEntrez Gene 25740 RatEntrez Gene 2781 Human
  UniProt ID P19086
• Background: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site. G protein z alpha, encoded by the GNAZ gene, is enriched in neural tissue and differs in sequence from other G alpha subunits. Alpha Subunits are encoded in 15 genes and several transcripts are alternatively spliced. Receptors may discriminate between splice variants; whether splice variants are functionally different in regulating effectors is not known. All alpha subunits appear to be palmitoylated near the N-terminus.
• Synonyms: G(x) alpha chain, Gz-alpha, GNAZ

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Long-term depression