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NPY receptor 2 / NPY2R Rabbit Polyclonal Antibody

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SKU
AP01323PU-N
NPY receptor 2 / NPY2R rabbit polyclonal antibody, Aff - Purified
Size:
100 ug
Conjugation:
Unconjugated
  $495.00
7 Weeks*
Bulk/Customize
Specifications
Specifications
Product Data
Application IF, IHC
Recommended Dilution IHC:1/50-200, IF:1/50-200
Reactivity Human, Mouse, Rat
Antibody Host Rabbit
Clonality Polyclonal
Immunogen Synthetic peptide, corresponding to amino acids 30-80 of Human NPY2-R.
Specificity This antibody detects endogenous levels of NPY2-R protein. (region surrounding Asp42)
Buffer Phosphate buffered saline (PBS) with 0.09% sodium azide, approx. pH 7.2.
State: Aff - Purified
State: Liquid purified Ig fraction
Concentration 1.0 mg/ml
Purification Affinity chromatography
Conjugation Unconjugated
Storage Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Stability Shelf life: one year from despatch.
Shipping Blue Ice
Predicted Protein Size ~ 43 kDa
Gene Name neuropeptide Y receptor Y2
Database Link
Background A gene on chromosome 4q31 encodes a 381 amino acid protein, NPY2-R(also designated Neuropeptide Y receptor Y2). NPY2-R is a member of the Gprotein-coupled receptor super-family, and like other members has seven putative transmembrane domains. However, NPY2-R gene consists of two exons, unlike the contiguous structure of other G-protein-coupled receptor genes. NPY2-R shares a 31% sequence identity with NPY1-R. NPY2-R is expressed in the presynaptic membranes of the central nervous system, and to a lesser extent the peripheral nervous system. NPY2-R associates (from highest to lowest affinity) with carboxyl terminals of unphosphorylate Peptide YY (PYY) (phosphorylation of PYY greatly reduces its binding affinity), NPY, and Pancreatic Peptide. Depending on the cell type, NPY2-R couples with different G proteins, which act as different second messengers. NPY2-R reduces the effects of depolarization, calcium ion currents in arterial smooth muscle by through association with NPY. NPY2-R inhibits cholecystokinin octapeptide-induced, esophageal muscle contraction, through interactions with PYY and NPY.
Synonyms NPY2-R, NPY-Y2 receptor, Y2 receptor, Neuropeptide Y receptor 2
Reference Data
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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