NPY receptor 2 / NPY2R Rabbit Polyclonal Antibody

SKU AP01323PU-N

NPY receptor 2 / NPY2R rabbit polyclonal antibody, Aff - Purified

Product Data

• Application: IF, WB
• Recommended Dilution: Western Blot: 1/500-1/1000.; Immunofluorescence: 1/50-1/200.; Immunohistochemistry: 1/50-1/200.
• Reactivity: Human, Mouse, Rat
• Antibody Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Synthetic peptide, corresponding to amino acids 30-80 of Human NPY2-R.
• Specificity: This antibody detects endogenous levels of NPY2-R protein. (region surrounding Asp42)
• Buffer: Phosphate buffered saline (PBS) with 0.09% sodium azide, approx. pH 7.2.; State: Aff - Purified; State: Liquid purified Ig fraction
• Concentration: 1.0 mg/ml
• Purification: Affinity chromatography
• Conjugation: Unconjugated
• Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.; Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Shipping: Blue Ice
• Predicted Protein Size: ~ 43 kDa
• Gene Name: neuropeptide Y receptor Y2
• Database Link:
  P97295
• Background: A gene on chromosome 4q31 encodes a 381 amino acid protein, NPY2-R(also designated Neuropeptide Y receptor Y2). NPY2-R is a member of the Gprotein-coupled receptor super-family, and like other members has seven putative transmembrane domains. However, NPY2-R gene consists of two exons, unlike the contiguous structure of other G-protein-coupled receptor genes. NPY2-R shares a 31% sequence identity with NPY1-R. NPY2-R is expressed in the presynaptic membranes of the central nervous system, and to a lesser extent the peripheral nervous system. NPY2-R associates (from highest to lowest affinity) with carboxyl terminals of unphosphorylate Peptide YY (PYY) (phosphorylation of PYY greatly reduces its binding affinity), NPY, and Pancreatic Peptide. Depending on the cell type, NPY2-R couples with different G proteins, which act as different second messengers. NPY2-R reduces the effects of depolarization, calcium ion currents in arterial smooth muscle by through association with NPY. NPY2-R inhibits cholecystokinin octapeptide-induced, esophageal muscle contraction, through interactions with PYY and NPY.
• Synonyms: NPY2-R, NPY-Y2 receptor, Y2 receptor, Neuropeptide Y receptor 2

Reference Data