EDG2 (LPAR1) Rabbit Polyclonal Antibody
$495.00
7 Weeks*
Specifications
| Product Data | |
| Application | IF, IHC, WB |
|---|---|
| Recommended Dilution | WB:1/500-1000;IHC:1/50-200;IF:1/50-200 |
| Reactivity | Human, Rat |
| Antibody Host | Rabbit |
| Clonality | Polyclonal |
| Immunogen | Synthetic peptide, corresponding to amino acids 10-62 of Human EDG-2. |
| Specificity | This antibody detects endogenous levels of EDG-2 protein. (region surrounding Trp45) |
| Buffer | Phosphate buffered saline (PBS), pH~7.2 State: Aff - Purified State: Liquid purified Ig fraction (> 95% pure by SDS-PAGE). Preservative: 0.05% Sodium Azide |
| Concentration | 1.0 mg/ml |
| Purification | Affinity Chromatography using epitope-specific immunogen. |
| Conjugation | Unconjugated |
| Storage | Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. |
| Stability | Shelf life: One year from despatch. |
| Shipping | Blue Ice |
| Predicted Protein Size | ~38 kDa |
| Gene Name | lysophosphatidic acid receptor 1 |
| Database Link | |
| Background | The EDG (endothelial differentiation gene) family of G protein-coupled receptors consists of eight family members that bind lysophospholipid (LPL) mediators, including sphingosine-1-phosphate (SPP) and lysophosphatidic acid (LPA). EDG-1, EDG-3, EDG-5 (also designated H218 and AGR16) and EDG-8 bind SPP with high affinity. EDG-6 is a low affinity receptor for SPP. LPA preferentially binds to EDG-2, EDG-4 and EDG-7. The EDG receptors couple to multiple G proteins to signal through Ras, MAP kinase, Rho, Phospholipase C or other tyrosine kinases, which lead to cell survival, growth, migration and differentiation. EDG-1 signals through Gi proteins to activate Akt and is expressed in glioma cells. EDG-2 is expressed in brain, especially in white matter tract regions, while EDG-3 is expressed in cardiovascular tissue and in cerebellum. EDG-4 is highly expressed on leukocytes and brain, and EDG-5 has wide tissue distribution, including cardiovascular tissue and brain. Expressed in lymphoid and hematopoietic tissues and in lung, EDG-6 signals through Gi/o proteins, which activate growth related pathways. |
| Synonyms | LPAR1, EDG2, LPA1, LPA receptor 1, LPA-1 |
| Reference Data | |
| Protein Categories | GPCR, Membrane Proteins |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Citations
Deficiency or inhibition of lysophosphatidic acid receptor 1 protects against hyperoxia-induced lung injury in neonatal rats
Chen, Walther, van Boxtel et al
Acta Physiol (Oxf) (2016) 216 (3), 358-75 DOI: 10.1111/apha.12622
Chen, Walther, van Boxtel et al
Acta Physiol (Oxf) (2016) 216 (3), 358-75 DOI: 10.1111/apha.12622
Cited by 23
AI Summary: In this study, OriGene products, specifically the Lpar1 (NM_021252) qPCR primer pair (catalog no. Rn00493268_m1), were used to measure mRNA expression levels of LPAR1 in rat lung tissues, contributing to the analysis of gene expression changes associated with hyperoxia-induced lung injury.
Showing 1-1 of 1 papers.
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complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.
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