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CD46 (Membrane Cofactor Protein) Mouse Monoclonal Antibody [Clone ID: 122.2]

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SKU
AM33360PU-S
CD46 (Membrane Cofactor Protein) mouse monoclonal antibody, clone 122.2, Purified
Size:
100 ug 20 ug
Conjugation:
Unconjugated
  $665.00
2 Weeks*
Bulk/Customize

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Specifications
Specifications
Product Data
Clone Name 122.2
Application FC, FN, IF, IHC, IP, WB
Recommended Dilution Functional Assays (Neutralization): Use Azide free Antibody.
Western Blot: 0.5-1 µg/ml.
Flow Cytometry: 0.5-1 µg/106 cells.
Immunoprecipitation: 1-2 µg/500 µg protein lysate.
Immunofluorescence: 1-2 µg/ml.
Immunohistochemistry on Frozen Sections: 0.5-1 µg/ml for 30 minutes at RT.
Recommended Positive Control: HeLa, K-562 or MOLT-4 cells, Kidney.
Reactivity Human
Antibody Host Mouse
Isotype IgG1
Clonality Monoclonal
Immunogen Recombinant human CD46 protein
Specificity Cellular Localization: Acrosome inner membrane, Cytoplasmic vesicle, Secretory vesicle
Buffer 200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Concentration lot specific
Purification Protein A/G Chromatography
Conjugation Unconjugated
Storage Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Stability Shelf life: one year from despatch.
Shipping Blue Ice
Predicted Protein Size 56-66kDa
Gene Name CD46 molecule
Database Link
Background CD46 acts as a cofactor for complement factor I, a serine protease, which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. It may be involved in the fusion of the spermatozoa with the oocyte during fertilization. CD46 acts as a co-stimulatory factor for T-cells, which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. A number of viral and bacterial pathogens seem to exploit this property and directly induce an immunosuppressive phenotype in T-cells by binding to CD46.
Synonyms AHUS2; CD46 antigen complement regulatory protein; Complement membrane cofactor protein; MCP; Measles virus receptor; Membrane cofactor protein; MIC10; TLX; Trophoblast leucocyte common antigen
Reference Data
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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