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CD8A (Cytotoxic-&Suppressor T-Cell Marker) Mouse Monoclonal Antibody [Clone ID: C8/468]

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SKU
AM32847PU-S
CD8A (Cytotoxic-&Suppressor T-Cell Marker) mouse monoclonal antibody, clone C8/468, Purified
Size:
100 ug
Conjugation:
Unconjugated
  $665.00
2 Weeks*
Bulk/Customize

View other "CD8A or NP_001139345.1" antibodies

Specifications
Specifications
Product Data
Clone Name C8/468
Application ELISA, FC, IF, IHC
Recommended Dilution ELISA: Use BSA free Antibody for coating.
Flow Cytometry: 1-2 µg/106 cells.
Immunofluorescence: 1-2 µg/ml.
Immunohistochemistry on Paraffin Sections: 1-2 µg/ml.
Incubation Time: 30 minutes at RT.
Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes.
Positive Control: HuT78 or hPBL, Human lymph node or tonsil.
Reactivity Human
Antibody Host Mouse
Isotype IgG1
Clonality Monoclonal
Immunogen Human CD8 recombinant protein
Specificity Cellular Localization: Cell membrane, Cell surface, Secreted
Buffer 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Concentration lot specific
Purification Protein A/G Chromatography
Conjugation Unconjugated
Storage Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Stability Shelf life: one year from despatch.
Shipping Blue Ice
Predicted Protein Size 32kDa
Gene Name CD8a molecule
Database Link
Background CD8 is a cell surface receptor expressed either as a heterodimer with the CD8 beta chain (CD8 alpha/beta) or as a homodimer (CD8 alpha/alpha). A majority of thymocytes and a subpopulation of mature T cells and NK cells express CD8a. CD8 binds to MHC class 1 and through its association with protein tyrosine kinase p56lck plays a role in T cell development and activation of mature T cells. For mature T-cells, CD4 and CD8 are mutually exclusive, so anti-CD8, generally used in conjunction with anti-CD4.It is a useful marker for distinguishing helper/inducer T-lymphocytes, and most peripheral T-cell lymphomas are CD4+/CD8-. Anaplastic large cell lymphoma is usually CD4+ and CD8-, and in T-lymphoblastic lymphoma/leukemia, CD4 and CD8 are often co-expressed. CD8 is also found in littoral cell angioma of the spleen.
Synonyms CD8 antigen, alpha polypeptide (p32), T8/Leu-2 T-lymphocyte differentiation antigen, Ly3, LYT3, MAL, T-cell surface glycoprotein CD8 alpha chain
Reference Data
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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