CD51 (ITGAV) Mouse Monoclonal Antibody [Clone ID: NKI-M9 (former PAF2a)]

CAT#: AM32337PU-N

CD51 (ITGAV) mouse monoclonal antibody, clone NKI-M9 (former PAF2a), Purified

Specifications

Product Data

• Clone Name: NKI-M9 (former PAF2a)
• Applications: ELISA, FN, IF, IHC, IP
• Recommended Dilution: ELISA.
  Functional Studies on Vitronectin Receptor on Human platelets.
  Flow Cytometry.
  Immunohistochemsitry on Frozen Sections.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG2a
• Clonality: Monoclonal
• Immunogen: Cultured melanoma cells derived from a Human melanoma metastasis.
• Specificity: The antibody is directed against the CD51 antigen, alpha chain of Vitronectin Receptor (VNR-alpha chain) which forms a complex with: CD61 antigen (GP IIIa or b3 chain); b5 Integrin and b1 Integrin.
  The platelet alpha-beta-3 complex functions as a Vitronectin Receptor and platelet adhesion to Vitronectin is inhibited by this monoclonal by NKI-M9 antibody.
• Formulation: PBS
  State: Purified
  State: Liquid purified IgG fraction
  Preservative: 0.09% Sodium Azide
• Concentration: lot specific
• Conjugation: Unconjugated
• Storage: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: integrin subunit alpha V
• Database Link:
  Entrez Gene 3685 Human
  UniProt ID P06756
• Background: CD51 (Cluster of Differentiation 51), known as vitronectin receptor α chain, or integrin αV is a type I integral membrane glycoprotein.
  CD51 forms a heterodimer with integrin β1 (CD29), β3 (CD61), β5, β6, or β8. CD51 contains two disulfide-linked subunits of 125 kD and 24 kD. Many extracellular matrix proteins with RGD-motifs are CD51 ligands. In association with its β chains, CD51 binds vitronectin, von Willebrand factor, fibronectin, thrombospondin, osteopontin, fibrinogen, and laminin. CD51, as an adhesion molecule, plays important roles in leukocytes homing and rolling, mediates bone absorption and angiogenesis.
  CD51 is expressed on endothelial cells, fibroblasts, macrophages, platelets, osteoclasts, neuroblastoma, melanoma, and hepatoma cells.
• Synonyms: Integrin alpha-V, MSK8, VNRA, Vitronectin receptor subunit alpha