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Mucin-5AC Mouse Monoclonal Antibody [Clone ID: 1-13M1]

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SKU
AM32160PU-N
Mucin-5AC mouse monoclonal antibody, clone 1-13M1, Purified
Size:
100 ug
Conjugation:
Unconjugated
  $600.00
2 Weeks*
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View other "MUC5AC" antibodies

Specifications
Specifications
Product Data
Clone Name 1-13M1
Application ELISA, IHC, R, WB
Recommended Dilution

Immunohistochemistry on cultured cells.
Immunochemistry on Frozen Ethanol Fixed Sections.
Immunochemistry on Paraffin Sections: a protease pretreatment is recommended.
This antibody clone 1-13M1 cross reacts with Mucin of different animal species after periodate pretreatment.
Immunoblotting: Strongly positive without mercaptoethanol pretreatment of mucin solution.
This antibody clone 1-13M1 recognizes Mucin 5AC under non-reducing conditions.
ELISA or IRMA in combination with the Clone 9-13M1 or the mixture of anti-M1 monoclonal antibodies.
Reactivity Human
Antibody Host Mouse
Isotype IgG1
Clonality Monoclonal
Immunogen A BALB/c mouse was immunized with Mucin isolated from an ovarian cyst fluid (pure endocervical type according to the Fenoglio's classisfication).
Splenocytes were fused with mouse myeloma SP2/0 cells.
Specificity This antibody clone 1-13M1 is specific for the peptide core of Gastric Mucin (MUC5AC), and more specifically with the 'a' epitope, which is the most abundant amongst the a,b,c,d,e,f, and h protein core epitopes defined by Bara for M1.
This antibody has not been cross-adsorbed and may react with related peptides from cat, cow, chicken, monkey, mouse, rat and rabbit.
The antibody is negative with hedgehog and pig.
Buffer PBS
State: Purified
State: Liquid purified IgG fraction
Preservative: 0.02% Sodium Azide
Concentration lot specific
Conjugation Unconjugated
Storage Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Stability Shelf life: one year from despatch.
Shipping Blue Ice
Gene Name mucin 5AC, oligomeric mucus/gel-forming
Database Link
Background Mucins are high molecular weight glycoproteins that are found especially in the secretions of mucus membranes. Gastric Mucin 5AC antigen is found in columnar mucus cells of surface gastric epithelium and in goblet cells of the fetal and precancerous colon but not in normal colon. Resurgence of gastric mucin during colonic carcinogenesis is suggestive of either re-expression of the peptide core of gastric mucin in the adult colon or due to changes in the glycosylation pattern of mucin, which expose the hidden Mucin 5AC antigen.
Synonyms MUC5AC, MUC5, TBM, LeB
Reference Data
Protein Categories ADC Targets, Secreated Proteins
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Documents
Resources

file-alt Citations

Comparison of the basic morphology and function of 3D lung epithelial cultures derived from several donors
Bovard, Giralt, Trivedi et al
Curr Res Toxicol (2020) 1, 56-69 DOI: 10.1016/j.crtox.2020.08.002
Cited by 22
AI Summary: OriGene products, specifically the CYP1A1/1B1 activity assay kits, were used in this study to measure cytochrome P450 enzyme activity in 3D lung epithelial cultures, enabling assessment of metabolic function and response to TCDD treatment across different donor-derived cultures.
FigureFigureFigure
Comparison of the basic morphology and function of 3D lung epithelial cultures derived from several donors
Bovard, Giralt, Trivedi et al
Current Research in Toxicology (2020) 1, 56-69 DOI: 10.1016/j.crtox.2020.08.002
Cited by 22
AI Summary: In this study, OriGene's anti-MUC5AC antibody (AM32160PU-N) was used for immunostaining to assess cell type composition in 3D lung epithelial cultures derived from different donors.
Snippet: ystem (Leica Biosystem Nussloch GmbH) by using a Leica BOND Polymer Refine Detection kit for anti-CC10 (Clone E11, Santa Cruz Biotechnologies, Inc., Santa Cruz, CA, USA) and anti-MUC5AC (AM32160PU-N, ACRIS Antibodies GmbH, Herford, Germany) primary antibodies. After staining, the slides were washed, dehydrated, and coverslipped by using the Leica CV5030 automated coverslipper (Leica Biosystems Nus
IHC
Showing 1-2 of 2 papers.
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