EPOR (Cytoplasm. Dom.) Rat Monoclonal Antibody [Clone ID: BCO-3H2]
$520.00
2 Weeks*
Specifications
| Product Data | |
| Clone Name | BCO-3H2 |
|---|---|
| Application | ELISA, FC, WB |
| Recommended Dilution | Flow Cytometry only on permeabilised cells: 1.2 μg/106 cells. ELISA: 1/200-1/400. Cell based ELISA only on permeabilised cells: 1/200-1/400. Western blot: See ref.5. Immunohistochemistry: See ref.5. |
| Reactivity | Human |
| Antibody Host | Rat |
| Isotype | IgG2b |
| Clonality | Monoclonal |
| Immunogen | Peptide immunisation from the cytoplasmic domain of human Epo-R |
| Specificity | This antibody detects Human Epo-R. Other species not tested. |
| Buffer | Phosphate buffered saline, pH 7.2 State: Purified State: Liquid Ig fraction |
| Purification | Protein G affinity chromatography |
| Conjugation | Unconjugated |
| Storage | Store undiluted at 2-8°C for one month or (in aliquots) at -20°C. Avoid repeated freezing and thawing. |
| Stability | Shelf life: one year from despatch. |
| Shipping | Blue Ice |
| Gene Name | erythropoietin receptor |
| Database Link | |
| Background | Erythropoietin receptor (Epo-R) belongs to the cytokine receptor family and is a 507 amino acid type I transmembrane protein. EpoR pre-exists as dimers which changes the homodimerized state after binding of its 34 kDa ligand erythropoietin (Epo) (1,2). Erythropoietin is the primary reg ulator of erythropoiesis, and promotes the survival, proliferation, and differentiation of erythroid progenitor cells. Both, Epo and Epo-R are essential for the production of red blood cells due to Epo exerts its function through the E po receptor (3). The Epo-R is also expressed in many organs outside the bone marrow, suggesting that Epo is a pleiotropic anti-apoptotic factor. Signaling pathways have been shown to influence numerous cellular functions in normal and tumor cells, including proliferation, apoptosis, and drug resistance (4). Development and specificity testing of the antibody are described in detail elsewhere (5). |
| Synonyms | EPOR, EPO-R |
| Reference Data | |
| Protein Categories | Cardiovascular diseases, Cytokines, Growth Factors, Membrane Proteins |
Reviews
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Citations
Novel antibodies directed against the human erythropoietin receptor: creating a basis for clinical implementation
Maxwell, Melendez-Rodríguez, Matchett et al
Br J Haematol (2015) 168 (3), 429-42 DOI: 10.1111/bjh.13133
Maxwell, Melendez-Rodríguez, Matchett et al
Br J Haematol (2015) 168 (3), 429-42 DOI: 10.1111/bjh.13133
Cited by 17
AI Summary: OriGene products, specifically the EPOR cDNA clone and EPOR shRNA, were used in this study to validate the specificity of newly developed EPOR antibodies by providing positive and negative controls in various assays.
Showing 1-1 of 1 papers.
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.
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