Neutrophil Elastase (ELANE) Mouse Monoclonal Antibody [Clone ID: 265-3K1]
$725.00
2 Weeks*
Specifications
| Product Data | |
| Clone Name | 265-3K1 |
|---|---|
| Application | ELISA, WB |
| Recommended Dilution | Immunoassays. Western blot: The typical starting working dilution is 1/50. |
| Reactivity | Human |
| Antibody Host | Mouse |
| Isotype | IgG1 |
| Clonality | Monoclonal |
| Specificity | The monoclonal antibody 265-3K1 recognizes Human Leukocyte Elastase. |
| Buffer | PBS State: Liquid 0.2 µm filtered Ig fraction Stabilizer: 0.1% BSA Preservative: 0.02% sodium azide |
| Concentration | lot specific |
| Purification | Protein G Chromatography |
| Conjugation | Unconjugated |
| Storage | Store undiluted at 2-8°C. |
| Stability | Shelf life: one year from despatch. |
| Shipping | Blue Ice |
| Gene Name | elastase, neutrophil expressed |
| Database Link | |
| Background | Leukocyte elastase, a major serine proteinase in man, is predominantly present in the azurophilic granules of neutrophils and monocytes. Elastase has a broad range of extracellular matrix substrates including elastin, proteoglycans, collagen and fibronectin. The action of elastase is controlled by serine proteinase inhibitors. Elastase, when released during inflammation, is rapidly bound by its two main inhibitors, alpha1-PI and alpha2-macroglobuline to form elastase-inhibitor complexes. In addition mucosa secretions may contain the locally secreted elastase inhibitors elafin/SKALP and SLPI. When secreted at sites of inflammation elastase can cause severe tissue damage. An important role has been suggested for human elastase in various inflammatory disorders, including pulmonary emphysema, sepsis, arthritis, nephritis and certain skin diseases. Elastase induces the production of IL-8 in human bronchial epithelial, a proces that occurs in part through TLR4. |
| Synonyms | ELANE, ELA2, Neutrophil elastase, Elastase-2, PMN elastase, Bone marrow serine protease, Medullasin, Human leukocyte elastase, HLE |
| Reference Data | |
| Protein Categories | Chemokines, Cytokines, Enzyme: Peptidases, Immune system diseases, Secreated Proteins |
Reviews
Documents
| Product Manuals |
| FAQs |
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Citations
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.
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