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Cd4 Rat Monoclonal Antibody [Clone ID: GK1.5]

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SKU
AM26029AC-N
Cd4 rat monoclonal antibody, clone GK1.5, APC
Size:
100 ug
Conjugation:
APC FITC PE
  $450.00
2 Weeks*
Bulk/Customize

View other "Cd4" antibodies

Specifications
Specifications
Product Data
Clone Name GK1.5
Application FC
Recommended Dilution Flow cytometry: 2 μg/ml.
Reactivity Mouse
Antibody Host Rat
Isotype IgG2b
Clonality Monoclonal
Immunogen Mouse CTL clone V4 cells
Specificity This antibody reacts with an extracellular epitope of mouse CD4 transmembrane glycoprotein (55 kDa).
Buffer Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4
Label: APC
State: Liquid purified Ig fraction
Label: Conjugated with cross-linked Allophycocyanin (APC) under optimum conditions. The conjugate is purified by size-exclusion chromatography.
Concentration lot specific
Conjugation APC
Storage Store the antibody at 2 - 8 °C. DO NOT FREEZE! This product is photosensitive and should be protected from light.
Stability Shelf life: one year from despatch.
Shipping Blue Ice
Gene Name CD4 antigen
Database Link
Background CD4 is a single chain transmembrane glycoprotein of immunoglobulin supergene family. In its extracellular region there are 4 immunoglobulin-like domains (1 Ig-like V-type and 3 Ig-like C2-type). The intracellular region of CD4 associates with p56Lck, a Src-like protein tyrosine kinase. It was described that CD4 segregates into specific detergent-resistant T-cell membrane microdomains. CD4 binds to MHC class II molecules (by CDR2-like region in CD4 domain 1), HIV envelope protein gp120 (by CDR2-like region in CD4 domain 1) and other ligands, such as IL-16 (by to CD4 domain 3) or L-selectin. CD4 is a co-receptor involved in immune response (co-receptor activity in binding to MHC class II molecules) and HIV infection. CD4 regulates T-cell activation, T/B-cell adhesion, T-cell diferentiation, T-cell selection and signal transduction. Defects in antigen presentation (MHC class II) cause dysfunction of CD4+ T-cells and their almost complete absence in patients blood, tissue and organs (SCID immunodeficiency).
Synonyms T-cell surface antigen T4/Leu-3
Reference Data
Protein Categories ADC Targets, CD Markers, Immune system diseases, Intracellular Proteins, Membrane Proteins
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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