CD45 / LCA Rat Monoclonal Antibody [Clone ID: EM-05]
$450.00
2 Weeks*
Specifications
| Product Data | |
| Clone Name | EM-05 |
|---|---|
| Application | FC |
| Recommended Dilution | Flow cytometry: 4 µg/ml as starting point. |
| Reactivity | Mouse |
| Antibody Host | Rat |
| Isotype | IgG |
| Clonality | Monoclonal |
| Immunogen | Murine peripheral blood leukocytes |
| Specificity | The antibody reacts with CD45 antigen (Leukocyte Common Antigen), a single chain type I transmembrane protein expressed at high level on cells of hematopoietic origin, except erythrocytes and platelets. |
| Buffer | Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4 Label: PerCP State: Liquid Ig fraction Label: Conjugated with Peridinin-chlorophyll-protein complex (PerCP) under optimum conditions. The conjugate is purified by size-exclusion chromatography. |
| Concentration | lot specific |
| Conjugation | PerCP |
| Storage | Store undiluted at 2-8°C. DO NOT FREEZE! This products is photosensitive and should be protected from light. |
| Stability | Shelf life: one year from despatch. |
| Shipping | Blue Ice |
| Gene Name | protein tyrosine phosphatase, receptor type, C |
| Database Link | |
| Background | CD45 (LCA, leukocyte common antigen) is a receptor-type protein tyrosine phosphatase ubiquitously expressed in all nucleated hematopoietic cells, comprising approximately 10% of all surface proteins in lymphocytes. CD45 glycoprotein is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases. CD45 protein exists as multiple isoforms as a result of alternative splicing; these isoforms differ in their extracellular domains, whereas they share identical transmembrane and cytoplasmic domains. These isoforms differ in their ability to translocate into the glycosphingolipid-enriched membrane domains and their expression depends on cell type and physiological state of the cell. Besides the role in immunoreceptor signaling, CD45 is important in promoting cell survival by modulating integrin-mediated signal transduction pathway and is also involved in DNA fragmentation during apoptosis. |
| Synonyms | PTPRC, Leukocyte common antigen, L-CA, T200 |
| Reference Data | |
| Protein Categories | ADC Targets, CD Markers, Cytokines, Growth Factors, Immune system diseases, Intracellular Proteins, Membrane Proteins |
Reviews
Documents
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Citations
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.
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