ERK1 / ERK2 Mouse Monoclonal Antibody [Clone ID: IL-13]
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Product Data | |
Clone Name | IL-13 |
Applications | IF, IHC, WB |
Recommended Dilution | Western Blot: 0.25 - 0.5 μg/ml. Immunohistochemistry on paraffin sections: 0.4 - 1 μg/ml. Immunocytochemistry. |
Reactivities | Human, Insect, Mouse, Rat, Yeast |
Host | Mouse |
Isotype | IgG1 |
Clonality | Monoclonal |
Specificity | This antibody reacts to ERK1 / ERK2. |
Formulation | 1.2 % sodium acetate, with 2 mg BSA and 0.01 mg sodium azide as preservative. State: Purified State: Lyphilized purified Ig fraction |
Reconstitution Method | Restore with 1.2% sodium acetate or neutral PBS |
Concentration | 0,1 mg/ml (after reconstitution with PBS) |
Purification | Affinity chromatography |
Conjugation | Unconjugated |
Storage | Prior to reconstitution store at -20°C. Following reconstitution store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. |
Stability | Shelf life: one year from despatch. |
Background | In mammalian cells, a variety of extracellular stimuli generate intracellular signals that converge on a limited number of so-called mitogen-activated protein (MAP) kinase pathways. The central core of each MAP kinase (MAPK) pathway is a conserved cascade of 3 protein kinases: an activated MAPK kinase kinase (MAPKKK) phosphorylates and activates a specific MAPK kinase (MAPKK), which then activates a specific MAPK. Mek1/2 MAPK kinases are essential for mammalian development, homeostasis, and Raf-induced hyperplasia. Germline mutations in genes within the MAPK pathway cause cardio-facio-cutaneous syndrome. |
Synonyms | ERK-1/ERK-2, MAPK1/MAPK2, P42/P44-MAPK |
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