CCR5 Mouse Monoclonal Antibody [Clone ID: T21/8]
$535.00
3 Weeks*
Specifications
| Product Data | |
| Clone Name | T21/8 |
|---|---|
| Application | ELISA, FC, IHC, IP, WB |
| Recommended Dilution | ELISA. Flow Cytometry: This T21/8 (T21/8) antibody has been tested by Flow cytometric analysis of normal human peripheral blood cells. This can be used at less than or equal to 0.5 µg per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µl. Cell number should be determined empirically but can range from 105 to 108 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. Immunohistochemistry on Paraffin Sections: 20 µg/ml. Immunoprecipitation. Western Blot. |
| Reactivity | Human |
| Antibody Host | Mouse |
| Isotype | IgG1 |
| Clonality | Monoclonal |
| Immunogen | Human CCR5 |
| Specificity | Recognizes C-C Chemokine Receptor 5 (CCR5). |
| Buffer | Aqeous buffer containing 0.09% Sodium Azide as preservative and may contain carrier protein/stabilizer State: Aff - Purified State: Liquid purified IgG fraction |
| Concentration | lot specific |
| Purification | Affinity Chromatography |
| Conjugation | Unconjugated |
| Storage | Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. |
| Stability | Shelf life: one year from despatch. |
| Shipping | Blue Ice |
| Gene Name | C-C motif chemokine receptor 5 (gene/pseudogene) |
| Database Link | |
| Background | Human CD195 is a member of the G protein coupled superfamily of receptors, which acts as a receptor for a number of chemokines including RANTES and also serves as a co-receptor for the entry of HIV into cells. It plays a key role in regulating the activation and migration of leukocytes. CD195 is expressed by a subset of T lymphocytes and by monocytes. CD195 is rapidly phosphorylated within the C-terminal domain upon ligand stimulation. Recent studies suggest that phosphorylation at Ser337 is mediated by Protein kinase C, whereas phosphorylation at Ser349 is mediated by GPCR kinases. |
| Synonyms | C-C chemokine receptor type 5, C-C CKR-5, CC-CKR-5, CCR-5, CMKBR5, CHEMR13 |
| Reference Data | |
| Protein Categories | Allergies and autoimmune diseases, CD Markers, Chemokines, Diabetes, GPCR, Membrane Proteins |
| Protein Families | Druggable Genome, ES Cell Differentiation/IPS, GPCR, Transmembrane |
| Protein Pathways | Chemokine signaling pathway, Cytokine-cytokine receptor interaction, Endocytosis |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Citations
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.
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