Dityrosine / DT Mouse Monoclonal Antibody [Clone ID: 1C3]
$385.00
2 Weeks*
Specifications
| Product Data | |
| Clone Name | 1C3 |
|---|---|
| Application | ELISA, IHC, WB |
| Recommended Dilution | ELISA (Ref.1,2) Western blot: 4 µg/ml (Ref.3,5) Immunohistochemistry on Paraffin Sections (Ref.4,6). |
| Reactivity | Human |
| Antibody Host | Mouse |
| Isotype | IgG2a |
| Clonality | Monoclonal |
| Immunogen | 3-(p-hydroxyphenyl) Propionic Acid Dimer, KLH-conjugated |
| Specificity | Specific for free Dityrosine, 3-(p-hydroxyphenyl) Propionic Acid dimer, Dityrosine-BSA conjugate, and Dityrosine in proteins or peptides. There was no cross reactivity detected for following compounds: Tyrosine, Nitrotyrosine, Chlorotyrosine, Aminotyrosine, Phosphotyrosine, 3-(phydroxyphenyl) Propionic Acid, Phenylalanine, 3,4-Dihydroxyphenylacetic Acid (DOPA). |
| Buffer | 10mM PBS, pH 7.4 State: Purified State: Lyophilized purified IgG fraction |
| Reconstitution Method | Restore in 0.2 ml aqua bidest to 0.1 mg/ml of IgG |
| Concentration | 0.1 mg/ml (after reconstitution) |
| Purification | Protein A Chromatography |
| Conjugation | Unconjugated |
| Storage | Store lyophilized at 2-8°C for 6 months or at -20°C long term. After reconstitution store the antibody undiluted (in aliquots) at -20°C. Avoid repeated freezing and thawing. |
| Stability | Shelf life: one year from despatch. |
| Shipping | Ambient |
| Background | Tyrosine is one of the major targets of protein oxidation, and until today various tyrosine derivatives such as nitrotyrosine, dityrosine and halogenated tyrosine depending on the type of free radicals. DT is a tyrosine dimer derived from tyrosyl radicals which is formed by reactive oxygen species (ROS), metal-catalyzed oxidation, ultraviolet irradiation, and peroxidases. DT have been found in atherosclerotic lesions, and lipofuscin of pyramidal neurons of aged human brains. Dityrosine is one of the specific biomarkers for protein oxidation. |
| Reference Data | |
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.
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