CDK7 Mouse Monoclonal Antibody [Clone ID: MO-1.1]
$495.00
2 Weeks*
Specifications
| Product Data | |
| Clone Name | MO-1.1 |
|---|---|
| Application | FC, IF, IHC, IP, WB |
| Recommended Dilution | Immunoblotting. Cell sorting (FACS analysis). Immunofluorescence. Immunoprecipitation of active kinase complex. Immunohistochemistry of Frozen Sections: 1/10-1/20 for 1h at RT. |
| Reactivity | Human |
| Antibody Host | Mouse |
| Isotype | IgG2b |
| Clonality | Monoclonal |
| Immunogen | Recombinant C-terminal 221 aa fragment of Human wild-type cdk7/CAK (cyclin activating kinase). |
| Specificity | Mo-1.1 recognizes the key cell cycle regulator cdk7, which is essential to activate the cdk2 kinase in G1 phase and the cdc2 kinase in G2/M phase. The antibody is useful for cell cycle analysis, cell proliferation studies and for Immunohistochemistry. |
| Buffer | PBS, pH 7.4 State: Aff - Purified State: Lyophilized purified IgG fraction Stabilizer: 0.5% BSA Preservative: 0.09% Soidum Azide |
| Reconstitution Method | Restore in 1 ml distilled water |
| Purification | Affinity Chromatography on Protein A |
| Conjugation | Unconjugated |
| Storage | Store lyophilized at 2-8°C for 6 months or at -20°C long term. After reconstitution store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C long term. Avoid repeated freezing and thawing. |
| Stability | Shelf life: one year from despatch. |
| Shipping | Ambient |
| Gene Name | cyclin-dependent kinase 7 |
| Database Link | |
| Background | Cdk7 is a member of the cyclin dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. Cdk7 forms a trimeric complex with cyclin H and MAT1, which functions as a Cdk activating kinase (CAK). It is an essential component of the transcription factor TFIIH, that is involved in transcription initiation and DNA repair. This protein is thought to serve as a direct link between the regulation of transcription and the cell cycle. |
| Synonyms | CAK1, P39 Mo15, STK1, CDK-activating kinase |
| Reference Data | |
| Protein Categories | Enzyme: Kinases, Intracellular Proteins |
| Protein Families | Druggable Genome, Protein Kinase, Stem cell - Pluripotency, Transcription Factors |
| Protein Pathways | Cell cycle, Nucleotide excision repair |
Reviews
Documents
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Citations
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.