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FKBP52 (FKBP4) Mouse Monoclonal Antibody [Clone ID: AT4D3]

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SKU
AM09071PU-N
Human FKBP52/FKBP4 antibody
Size:
100 ul 50 ul
Conjugation:
Unconjugated
  $465.00
3 Weeks*
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View other "FKBP52 or NP_002005" antibodies

Specifications
Specifications
Product Data
Clone Name AT4D3
Application ELISA, FC, ICC, IHC, WB
Recommended Dilution ELISA.
Western blot (1/1,000-1/2,000).
Cell lysates of HeLa (40 µg) were resolved by SDS-PAGE, transferred to NC membrane and probed with anti-human FkBP4 (1/1000). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system.
Immunohistochemistry on Paraffin Embedded Tissue (1/50-1/100).
Paraffin embedded sections of Seminoma (Germ cell tumor) tissue were incubated with anti-Human FKBP4 (1/50) for 2 hours at RT. Antigen retrieval was performed in 0.1M sodium citrate buffer and detected using Diaminobenzidine (DAB).
Reactivity Human
Antibody Host Mouse
Isotype IgG2b, kappa
Clonality Monoclonal
Immunogen Recombinant human FkBP4 (1-459aa) purified from E. coli
Specificity The antibody recognizes Human FKBP4. Other species not tested.
Buffer Liquid in. Phosphate-Buffered Saline (pH 7.4) with 0.02% Sodium Azide, 10% glycerol
Concentration 1mg/ml (determined by BCA assay)
Purification By protein-G affinity chromatography
Conjugation Unconjugated
Storage Can be stored at +2°C to +8°C for 1 week. For long term storage, aliquot and store at -20°C to -80C. Avoid repeated freezing and thawing cycles.
Stability Shelf life: one year from despatch.
Shipping Blue Ice
Gene Name FK506 binding protein 4
Database Link
Background FkBP4, also known as FkBP52, is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. It is a component of unactivated mammalian steroid receptor complexes and may play a role in the intracellular trafficking of hetero-oligomeric forms of the steroid hormone receptors. It interacts with interferon regulatory factor-4 and plays an important role in immunoregulatory gene expression in B and T lymphocytes.
Synonyms FK506 binding protein 4, FK506 binding protein 4 52 kDa FK506 binding protein, FKBP 4, FKBP 52, FKBP 59, HBI, Hsp 56, HSP binding immunophilin, p52, p59 protein, Peptidylprolyl cis trans isomerase, PPIase, Rotamase, T cell FK506 binding protein 59kD
Reference Data
Protein Categories Growth Factors, Intracellular Proteins
Protein Families Druggable Genome
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Documents
Resources

file-alt Citations

Suppression of TDO-mediated tryptophan catabolism in glioblastoma cells by a steroid-responsive FKBP52-dependent pathway
Ott, Litzenburger, Rauschenbach et al
Glia (2015) 63 (1), 78-90 DOI: 10.1002/glia.22734
Cited by 61
AI Summary: In this study, OriGene’s FKBP52 shRNA (TG312896) and FKBP52 cDNA (RC217709) products were used to manipulate FKBP52 expression in glioblastoma cells, enabling the authors to demonstrate FKBP52’s key role in regulating TDO-mediated tryptophan catabolism.
Showing 1-1 of 1 papers.
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