SARM (SARM1) (93-292) Mouse Monoclonal Antibody [Clone ID: Sarmy-1]

CAT#: AM08374PU-N

SARM (SARM1) (93-292) mouse monoclonal antibody, clone Sarmy-1, Purified

Product Images

Formalin-Fixed Paraffin-Embedded Human Brain, Cortex stained with SARM1 antibody. at 10 ug/ml followed by biotinylated anti-mouse IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Specifications

Product Data

• Clone Name: Sarmy-1
• Applications: IHC, IP
• Recommended Dilution: Immunohistochemistry on Paraffin Sections: 10 µg/ml.
  Immunoprecipitation: 1/200.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG2b
• Clonality: Monoclonal
• Immunogen: Recombinant human SARM (aa 93-292)
• Specificity: This antibody recognizes human SARM.
• Formulation: PBS containing 10% Glycerol and 0.02% Sodium Azide as preservative
  State: Purified
  State: Liquid purified Ig fraction
• Concentration: lot specific
• Conjugation: Unconjugated
• Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C to -70°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Database Link:
  Entrez Gene 23098 Human
  UniProt ID Q6SZW1
• Background: Toll-like receptors (TLRs) play an essential role in the detection and elimination of invading microbes. They are type-1 transmembrane receptors, containing extracellular leucine rich repeats and an intracellular Toll/interleukin-1 receptor (TIR) domain. Upon stimulation, these receptors interact with specific TIR domain-containing adaptor proteins. Five such adaptors have been discovered to date, MyD88, Mal (MyD88 adaptor-like)/TIRAP (TIR domain-containing adaptor protein), Trif (TIR-domain-containing adaptor inducing interferon-beta), TRAM (Trif-related adaptor molecule) and SARM (SAM and ARM-containing protein). Different TLRs use different combinations of these adaptors, leading to the activation of common and unique pathways involved in the elimination of the invading microbe.
• Synonyms: SARM, SAMD2, KIAA0524