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SARM (SARM1) (93-292) Mouse Monoclonal Antibody [Clone ID: Sarmy-1]

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SKU
AM08374PU-N
SARM (SARM1) (93-292) mouse monoclonal antibody, clone Sarmy-1, Purified
Size:
50 ug
Conjugation:
Unconjugated
  $605.00
3 Weeks*
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View other "SARM1 or NP_055892.2" antibodies

Specifications
Specifications
Product Data
Clone Name Sarmy-1
Application IHC, IP
Recommended Dilution Immunohistochemistry on Paraffin Sections: 10 µg/ml.
Immunoprecipitation: 1/200.
Reactivity Human
Antibody Host Mouse
Isotype IgG2b
Clonality Monoclonal
Immunogen Recombinant human SARM (aa 93-292)
Specificity This antibody recognizes human SARM.
Buffer PBS containing 10% Glycerol and 0.02% Sodium Azide as preservative
State: Purified
State: Liquid purified Ig fraction
Concentration lot specific
Conjugation Unconjugated
Storage Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C to -70°C for longer.
Avoid repeated freezing and thawing.
Stability Shelf life: one year from despatch.
Shipping Blue Ice
Gene Name sterile alpha and TIR motif containing 1
Database Link
Background Toll-like receptors (TLRs) play an essential role in the detection and elimination of invading microbes. They are type-1 transmembrane receptors, containing extracellular leucine rich repeats and an intracellular Toll/interleukin-1 receptor (TIR) domain. Upon stimulation, these receptors interact with specific TIR domain-containing adaptor proteins. Five such adaptors have been discovered to date, MyD88, Mal (MyD88 adaptor-like)/TIRAP (TIR domain-containing adaptor protein), Trif (TIR-domain-containing adaptor inducing interferon-beta), TRAM (Trif-related adaptor molecule) and SARM (SAM and ARM-containing protein). Different TLRs use different combinations of these adaptors, leading to the activation of common and unique pathways involved in the elimination of the invading microbe.
Synonyms SARM, SAMD2, KIAA0524
Reference Data
Protein Categories Intracellular Proteins
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Documents
Resources

file-alt Citations

Activation of TLR3 Promotes the Degeneration of Retinal Ganglion Cells by Upregulating the Protein Levels of JNK3
Chintala, Putris, Geno
Invest. Ophthalmol. Vis. Sci. (2015) 56 (1), 505-14 DOI: 10.1167/iovs.14-15539
Cited by 23
AI Summary: OriGene's SARM1 antibody was used for Western blot analysis to detect SARM1 protein levels in retinal extracts, contributing to the investigation of molecular changes during retinal ganglion cell degeneration in the study.
Snippet: WI, USA), respectively. SARM1 antibodies were obtained either from Origene (Rockville, MD, USA;for Western blot analysis) or from GenWay Biotech, Inc. (San Diego, CA, USA;for immunohistochemistry). Antibodies against ... Related articles All 4 versions Cite SaveSaving
WB IHC
Excitotoxicity upregulates SARM1 protein expression and promotes Wallerian-like degeneration of retinal ganglion cells and their axons
Massoll, Mando, Chintala
Invest. Ophthalmol. Vis. Sci. (2013) 54 (4), 2771-80 DOI: 10.1167/iovs.12-10973
Cited by 39
AI Summary: In this study, OriGene's primary antibodies against SARM1 were used for Western blot analysis to measure SARM1 protein levels in retinal tissue following excitotoxic injury.
Snippet: Louis, MO). For Western blot analysis of SARM1, primary antibodies were obtained from Origene (Rockville, MD). ... Sarm1 silencer predesigned siRNA (cat# AM16708) and silencer negative control siRNA (cat# AM4611) were obtained from Life Technologies (Grand Island, NY).
WB IHC
Showing 1-2 of 2 papers.
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