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LOC396098 (Bu1a + Bu1b) Mouse Monoclonal Antibody [Clone ID: AV20]

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SKU
AM08139RP-N
LOC396098 (Bu1a + Bu1b) mouse monoclonal antibody, clone AV20, PE
Size:
100 ug
Conjugation:
PE Biotin FITC Unconjugated
  $500.00
3 Days*
Bulk/Customize
Specifications
Specifications
Product Data
Clone Name AV20
Application FC
Recommended Dilution Flow Cytometry: < / = 0.2 µg/10e6 cells. (Ref.2)
Reactivity Chicken
Antibody Host Mouse
Isotype IgG1
Clonality Monoclonal
Immunogen Bursal cells from one-day-old H.B15 (Bu-1a/b) strain chickens. (Ref.1)
Specificity This antibody recognizes a monomorphic determinant on the Bu-1 B cell associated alloantigens of both RPL 6(3) (Bu-1a) and 7(2) (Bu-1b) lines of inbred chickens. It also identifies B cells in partially inbred birds. Bu-1 is found on 85-90% of bursal cells, 2-8% of thymocytes, 15-27% of spleen cells, and 2-18% of peripheral blood cells. It is also expressed on subsets of macrophages and monocytes, but not on granulocytes, erythrocytes or thrombocytes. (Ref.1-2) No Cross reactivity is observed with Turkey cells when analyzed by Immunofluorescent staining and Flow Cytometry.
Buffer PBS containing 0.09% Sodium Azide as preservative and a stabilizing agent.
Label: PE
State: Liquid purified Ig fraction.
Label: R-Phycoerythrin
Concentration lot specific
Conjugation PE
Storage Store the antibody undiluted at 2-8°C.
DO NOT FREEZE!
This product is photosensitive and should be protected from light.
Avoid repeated freezing and thawing.
Stability Shelf life: one year from despatch.
Shipping Blue Ice
Gene Name B6.1
Database Link
Background The Bu1 chB6 molecule is expressed on chicken B cells throughout most of their development, as well as on some non lymphoid cells. It has long been used as an allotypic marker in important studies of B cell development, though its function is unknown. It has no recognizable similarity to known mammalian molecules and thus represents a unique B cell marker. Its presence in chickens may be related to differences in the properties of B cell development between chickens and mammalian species. The sequences of the different alleles of this gene revealed a higher level of polymorphism than expected. A restriction fragment length polymorphism linked to the CHB6 gene has been used to determine its location on the linkage map of the chicken genome, which will allow the definitive evaluation of reported associations with disease resistance.
Synonyms B-Cell Marker
Reference Data
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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