CD11b Rat Monoclonal Antibody [Clone ID: 3A33]
Specifications
| Product Data | |
| Clone Name | 3A33 |
|---|---|
| Application | FC |
| Recommended Dilution | Flow Cytometry: ? 0.3 µg/106 cells (Ref.1). |
| Reactivity | Mouse |
| Antibody Host | Rat |
| Isotype | IgG2a |
| Clonality | Monoclonal |
| Immunogen | Peritoneal macrophages from C57 B1/6 x DBA/2 F1 hybrid mice. (Ref.1) |
| Specificity | This antibody is specific to Alpha M subunit (Mr 170 kDa) of the CD11b/CD18 heterodimer. |
| Buffer | PBS containing 0.09% Sodium Azide as preservative and a stabilizing agent. Label: APC-Cy7 State: Liquid purified Ig fraction. Label: Allophycocyanin-Cyanine 7 |
| Concentration | lot specific |
| Conjugation | APC-Cy7 |
| Storage | Store the antibody undiluted at 2-8°C. DO NOT FREEZE! This product is photosensitive and should be protected from light. Avoid repeated freezing and thawing. |
| Stability | Shelf life: one year from despatch. |
| Shipping | Blue Ice |
| Database Link | |
| Background | CD11b (Integrin alpha M subunit) combines with CD18 (Integrin beta2 subunit) to form the integrin Mac-1, also known as complement receptor 3 (CR3), which mediates adhesion to C3bi and ICAM-1 (CD54). (Ref.2-6) Mac-1 is expressed at varying levels on granulocytes, macrophages, dendritic cells, NK cells, and B-1 cells in the peritoneal and pleural cavities. (Ref.2,7-10) In addition to its role in binding C3bi on opsonized targets and mediation of the subsequent ingestion process. (Ref.4,11) Mac-1 is important as an adhesion molecule in the transendothelial migration of monocytes and neutrophils. (Ref.12) |
| Synonyms | ITGAM, CR3A, CR-3 alpha chain, Integrin alpha-M, MAC1 |
| Reference Data | |
| Protein Categories | CD Markers, Intracellular Proteins, Membrane Proteins |
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Citations
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.
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