TAB2 Mouse Monoclonal Antibody [Clone ID: 3B5]
Specifications
| Product Data | |
| Clone Name | 3B5 |
|---|---|
| Application | ELISA, FC, WB |
| Recommended Dilution | ELISA: 1/10000. Western Blot: 1/500 - 1/2000. Flow Cytometry: 1/200 - 1/400. |
| Reactivity | Human |
| Antibody Host | Mouse |
| Isotype | IgG1 |
| Clonality | Monoclonal |
| Immunogen | Purified recombinant fragment of Human TAB2 expressed in E. Coli. |
| Specificity | Recognizes TAB2 / MAP3K7IP2 |
| Buffer | State: Ascites State: Ascitic fluid containing 0.03% Sodium Azide. |
| Conjugation | Unconjugated |
| Storage | Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. |
| Stability | Shelf life: one year from despatch. |
| Shipping | Blue Ice |
| Predicted Protein Size | 80 kDa |
| Gene Name | TGF-beta activated kinase 1/MAP3K7 binding protein 2 |
| Database Link | |
| Background | The protein encoded by this gene is an activator of MAP3K7/TAK1, which is required for for the IL-1 induced activation of nuclear factor kappaB and MAPK8/JNK. This protein forms a kinase complex with TRAF6, MAP3K7 and TAB1, thus serves as an adaptor linking MAP3K7 and TRAF6. This protein, TAB1, and MAP3K7 also participate in the signal transduction induced by TNFSF11/RANKl through the activation of the receptor activator of NF-kappB (TNFRSF11A/RANK), which may regulate the development and function of osteoclasts. |
| Synonyms | TAK1-binding protein 2, Tab-2, Mitogen-activated protein kinase kinase kinase 7-interacting protein 2 |
| Reference Data | |
| Protein Categories | Intracellular Proteins |
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