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Pirh2 (RCHY1) Mouse Monoclonal Antibody [Clone ID: 1H10]

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SKU
AM06384SU-N
Pirh2 (RCHY1) mouse monoclonal antibody, clone 1H10, Ascites
Size:
100 ul
Conjugation:
Unconjugated
  $580.00
2 Weeks*
Bulk/Customize

View other "RCHY1 or NP_001008925.1" antibodies

Specifications
Specifications
Product Data
Clone Name 1H10
Application ELISA, FC, IF, IHC, WB
Recommended Dilution ELISA: 1/10000.
Western Blot: 1/500-1/2000.
Immunofluorescence: 1/200-1/1000.
Flow Cytometry: 1/200-1/400.
Immunohistochemistry on Paraffin Sections: 1/200-1/1000.
Reactivity Human, Rat
Antibody Host Mouse
Isotype IgG1
Clonality Monoclonal
Immunogen Purified recombinant fragment of Human Pirh2 expressed in E. Coli.
Specificity This antibody recognizes Ring Finger and CHY Zinc Finger Domain Containing 1 (RCHY1).
Buffer State: Ascites
State: Ascitic fluid
Preservative: 0.03% Sodium Azide
Conjugation Unconjugated
Storage

Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Stability Shelf life: one year from despatch.
Shipping Blue Ice
Predicted Protein Size 30 kDa; 60 kDa (homodimer)
Gene Name ring finger and CHY zinc finger domain containing 1
Database Link
Background Pirh 2 (P53 induced RING-H2 protein), also known as RCHY1, it forms dimers through its N- and C-terminus in cells. The Pirh2 has ubiquitin-protein ligase activity and it binds with p53 and promotes the ubiquitin-mediated proteosomal degradation of p53. The Pirh2 is oncogenic because loss of p53 function contributes directly to malignant tumor development. Pirh2 expression decreases the level of p53, and a decrease of endogenous Pirh2 expression increases p53 levels. Pirh2 is therefore considered, together with MDM2, to act as a negative regulator of p53 function.
Synonyms ARNIP, CHIMP, RNF199, ZNF363
Reference Data
Protein Categories Intracellular Proteins
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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