Islet 1 (ISL1) Mouse Monoclonal Antibody [Clone ID: 1H9]
Specifications
| Product Data | |
| Clone Name | 1H9 |
|---|---|
| Application | ELISA, IF, IHC, WB |
| Recommended Dilution | ELISA: 1/10000. Western Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. Immunohistochemistry on Paraffin Sections: 1/200 - 1/1000. |
| Reactivity | Human |
| Antibody Host | Mouse |
| Isotype | IgG1 |
| Clonality | Monoclonal |
| Immunogen | Purified recombinant fragment of human ISL1 expressed in E. Coli. |
| Specificity | Recognizes ISL1 (ISL1 transcription factor). |
| Buffer | State: Ascites State: Ascitic fluid containing 0.03% Sodium Azide. |
| Conjugation | Unconjugated |
| Storage | Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. |
| Stability | Shelf life: one year from despatch. |
| Shipping | Blue Ice |
| Predicted Protein Size | 39 kDa |
| Gene Name | ISL LIM homeobox 1 |
| Database Link | |
| Background | ISL1 (ISL1 transcription factor, LIM/homeodomain) is a member of the LIM/homeodomain family of transcription factors. It binds to the enhancer region of the insulin gene, among others, and may play an important role in regulating insulin gene expression. It is central to the development of pancreatic cell lineages and may also be required for motor neuron generation. Islet-1 expression defines cardiac progenitor cell populations and is required for normal cardiac development and asymmetry. Mutations in this gene have been associated with maturity-onset diabetes of the young. |
| Synonyms | Isl-1; islet-1; ISLET1 |
| Reference Data | |
| Protein Categories | Growth Factors, Intracellular Proteins, Transciption Factors |
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