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E7 Mouse Monoclonal Antibody [Clone ID: 3D6F1]

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SKU
AM06265SU-N
E7 mouse monoclonal antibody, clone 3D6F1, Ascites
Size:
100 ul
Conjugation:
Unconjugated
  $580.00
2 Weeks*
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View other "Early Protein E7" antibodies

Specifications
Specifications
Product Data
Clone Name 3D6F1
Application WB
Recommended Dilution ELISA: 1/10000.
Western Blot: 1/500 - 1/2000.
Reactivity Human Papilloma Virus 16
Antibody Host Mouse
Isotype IgG1
Clonality Monoclonal
Immunogen Purified recombinant fragment of E7 expressed in E. Coli.
Specificity Recognizes HPV16 E7 (Human papillomavirus type 16 E7).
Buffer State: Ascites
State: Ascitic fluid containing 0.03% Sodium Azide.
Conjugation Unconjugated
Storage

Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Stability Shelf life: one year from despatch.
Shipping Blue Ice
Database Link
Background E7 transforming protein (Human papillomavirus type 16) has both transforming and trans-activating activities. Disrupts the function of host retinoblastoma protein RB1/pRb, which is a key regulator of the cell cycle. Induces the disassembly of the E2F1 transcription factors from RB1, with subsequent transcriptional activation of E2F1-regulated S-phase genes. Inactivation of the ability of RB1 to arrest the cell cycle is critical for cellular transformation, uncontrolled cellular growth and proliferation induced by viral infection. Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication. Interferes with histone deacetylation mediated by HDAC1 and HDAC2, leading to activation of transcript.
Synonyms Human Papilloma Virus Early protein 7
Reference Data
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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