IRF3 Mouse Monoclonal Antibody [Clone ID: 3F10]
Specifications
| Product Data | |
| Clone Name | 3F10 |
|---|---|
| Application | ELISA, IF, WB |
| Recommended Dilution | ELISA. Western blot (1:1000 - 1:2000), recommended starting dilution is 1:1000. Immunoprecipitation. Immunoflourescence. |
| Reactivity | Human |
| Antibody Host | Mouse |
| Isotype | IgG1 |
| Clonality | Monoclonal |
| Immunogen | Recombinant human IRF3 (108-166 aa) purified from E.coli |
| Specificity | The antibody recognizes human interferon regulatory factor 3 (IRF3), a 55 kDa constitutively expressed member of the IRF family. Other species not tested. |
| Buffer | PBS, pH 7.4 containing 0.02% Sodium Azide and 10% Glycerol State: Purified State: Liquid purified Ig fraction |
| Concentration | lot specific |
| Purification | Protein-G affinity chromatography |
| Conjugation | Unconjugated |
| Storage | Store undiluted at 2-8°C for up to two weeks or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. |
| Stability | Shelf life: one year from despatch. |
| Shipping | Blue Ice |
| Gene Name | interferon regulatory factor 3 |
| Database Link | |
| Background | Members of the Interferon regulatory factor (IRF) family regulate gene expression critical to immune response, hemopoiesis, and proliferation. IRF-3 is distinct from other family members. Its transcriptional activity is regulated solely by posttranslational modifications. It plays a crucial role in activation of innate immunity and inflammation in response to viral infection. IRF3 accumulates in an inactive form in the cytoplasm and then translocates to the nucleus as a homodimer, following stimuli-induced phosphorylation of specific serine/threonine residues. Association of the homodimer with p300/CBP (CREBB binding protein) forms dsRNA-activated factor 1 (DRAF1), which then activates the transcription of interferon alpha and beta, along with other interferon-induced genes. |
| Synonyms | Interferon regulatory factor 3, IRF-3 |
| Reference Data | |
| Protein Categories | Cytokines, Intracellular Proteins, Nervous system Diseases, Transciption Factors |
Reviews
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Citations
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.
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