ARAP1 Mouse Monoclonal Antibody [Clone ID: ARAP1-2]
Specifications
| Product Data | |
| Clone Name | ARAP1-2 |
|---|---|
| Application | IF, IP, WB |
| Recommended Dilution | Suitable for Western Blotting (2 μg/ml). Immunoprecipitation. Immunocytochemistry. |
| Reactivity | Human |
| Antibody Host | Mouse |
| Isotype | IgG1 |
| Clonality | Monoclonal |
| Immunogen | His6-tagged protein corresponding to amino acids 1190-1450 of human ARAP1 |
| Specificity | The antibody ARAP1-2 reacts with C-terminal part of ARAP1, a 160 kDa adaptor protein. |
| Buffer | PBS, pH 7.4 with 15 mM sodium azide as preservative. State: Aff - Purified State: Liquid purified Ig fraction (> 95% pure by SDS-PAGE) |
| Concentration | lot specific |
| Purification | Protein A affinity chromatography |
| Conjugation | Unconjugated |
| Storage | Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid freeze/thaw cycles. |
| Stability | Shelf life: One year from despatch. |
| Shipping | Blue Ice |
| Gene Name | ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 |
| Database Link | |
| Background | ARAP1 (angiotensin II type 1 receptor-associated protein) is an adaptor protein with ArfGAP and RhoGAP activities, containing five PH domains and ankyrin repeate. This adaptor seems to serve as a link between phosphoinositide- Arf-, and Rho-mediated cell signaling. ARAP1 supports the plasma membrane recycling of angiotensin II type 1 receptor (AT1) and is important also for cell-specific trafficking of pro-death receptor TRAIL-R1 (DR4) to the plasma membrane, thus promoting the TRAIL-induced apoptosis in certain cell types. ARAP1 also affects cell spreading. |
| Synonyms | KIAA0782, Centaurin-delta-2 |
| Reference Data | |
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