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Sponge Hsp70 Mouse Monoclonal Antibody [Clone ID: IVF5]

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SKU
AM02038PU-N
Sponge Hsp70 mouse monoclonal antibody, clone IVF5, Purified
Size:
100 ug
Conjugation:
Unconjugated
  $795.00
2 Weeks*
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View other "hsp70" antibodies

Specifications
Specifications
Product Data
Clone Name IVF5
Application ELISA, IHC, IP, WB
Recommended Dilution ELISA: 1/5,000.
Western blot: 1/500.
Immunoprecipitation: 1/50.
Immunohistochemistry: 1/50.
Reactivity Geodia cydonium
Antibody Host Mouse
Isotype IgG1
Clonality Monoclonal
Immunogen HSP70 from Geodia cydonium.
Specificity This antibody detects HSP70.
Buffer 50mM TRIS pH 7.4
State: Purified
State: Lyophilized IgG fraction
Reconstitution Method Restore in aqua bidest to 1 mg/ml.
Purification Protein G chromatography
Conjugation Unconjugated
Storage Store lyophilized at 2-8°C and reconstituted at -20°C.
Avoid repeated freezing and thawing.
Stability Shelf life: One year from despatch.
Shipping Ambient
Database Link
Background Heat shock proteins (HSPs) or stress response proteins (SRPs) are synthesized in variety of environmental and pathophysiological stressful conditions. Many HSPs are involved in processes such as protein denaturation-renaturation, folding-unfolding, transport-translocation, activation-inactivation, and secretion. HSP70 is found to be associated with steroid receptors, actin, p53, polyoma T antigen, nucleotides, and other unknown proteins. Also, HSP70 has been shown to be involved in protective roles against thermal stress, cytotoxic drugs, and other damaging conditions.

Heat shock proteins are produced by prokaryotic and eukaryotic cells, and are among the most conserved molecules in phylogeny. Eukaryotic cells contain an HSP70 multigene that differ in their intracellular location and regulation. Members of the HSP70 family play a major role in the folding, unfolding and translocation of polypeptides as well as in the assembly and disassembly of oligomeric protein complexes, as well as in the immune response. HSP72 was found to increase dramatically in the brains of Alzheimer’s disease patients, and was localized exclusively in neuritic plaques and neurofibrillary tangles. HSP70 concentrates in nuclei during heat shock and returns to the cytoplasm when the shock is removed.
Synonyms Heat Shock Protein 70
Reference Data
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Documents
Resources

file-alt Citations

TRPM4 channel is involved in regulating epithelial to mesenchymal transition, migration, and invasion of prostate cancer cell lines
Sagredo, Sagredo, Pola et al
J. Cell. Physiol. (2018)
AI Summary: OriGene's Prostate Cancer cDNA Array II was used in this study to analyze TRPM4 expression levels in prostate cancer patient samples, enabling the investigation of its association with tumor aggressiveness and EMT-related processes.
Snippet: penicillin/streptomycin (Hyclone Laboratories, Logan, UT). 2.2 cDNAs from patient samples. Prostate Cancer cDNA Array II was acquired from Origene (Origene, Rockville, MO). This cancer panel contemplates complementary
Array
TRPM4 regulates Akt/GSK3-β activity and enhances β-catenin signaling and cell proliferation in prostate cancer cells
Sagredo, Sagredo, Cappelli et al
Mol Oncol (2017)
AI Summary: OriGene products, specifically the mouse anti-TRPM4b antibody (TA500381) and rabbit anti-phospho-S9 GSK-3β antibody (TA303847), were used in this study to detect and analyze protein levels and phosphorylation states critical for elucidating the role of TRPM4 in prostate cancer cell signaling and proliferation.
Snippet: … Mouse anti-TRPM4b (Origene, TA500381), mouse anti-β-catenin (BD Biosciences, 610154), ... Published by FEBS Press and John Wiley & Sons Ltd. 610201), rabbit anti-phospho-S9 GSK-3β (Origene, TA303847), rabbit anti-Akt1 (Cell ...;... … Mouse anti-TRPM4b (Origene, TA500381), mouse anti-β-catenin (BD Biosciences, 610154), ... Published by FEBS Press and John Wiley & Sons Ltd. 610201), rabbit anti-phospho-S9 GSK-3β (Origene, TA303847), rabbit anti-Akt1 (Cell
Showing 1-2 of 2 papers.
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