HIF-1 alpha (HIF1A) Goat Polyclonal Antibody
Specifications
| Product Data | |
| Application | WB |
|---|---|
| Recommended Dilution | WB 1:500-1:2,000 |
| Reactivity | Canine, Human, Mouse |
| Antibody Host | Goat |
| Isotype | IgG |
| Clonality | Polyclonal |
| Immunogen | Purified recombinant peptide derived from within residues 780 aa to the C-terminus of human HIF1a produced in E. coli. |
| Specificity | Detects HIF1a in transfected cells and a band of approximately 120 kDa by Western blot in cell lysates. |
| Buffer | Polyclonal antibody supplied as a 200 µl (3 mg/ml) aliquot in PBS, 20% glycerol and 0.05% sodium azide. |
| Concentration | 3mg/ml |
| Purification | epitope affinity purified |
| Conjugation | Unconjugated |
| Shipping | Blue Ice |
| Gene Name | hypoxia inducible factor 1 alpha subunit |
| Database Link | |
| Background | Hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) |
| Synonyms | bHLHe78; HIF-1alpha; HIF1; HIF1-ALPHA; MOP1; PASD8 |
| Note | Detects HIF1a in transfected cells and a band of approximately 120 kDa by Western blot in cell lysates. |
| Reference Data | |
| Protein Categories | Cancer: Head and Neck, Chemokines, Cytokines, Growth Factors, Intracellular Proteins, Transciption Factors |
| Protein Families | Transcription Factors |
| Protein Pathways | mTOR signaling pathway, Pathways in cancer, Renal cell carcinoma |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Citations
Methylglyoxal-induced glycation changes adipose tissue vascular architecture, flow and expansion, leading to insulin resistance
Rodrigues, Matafome, Sereno et al
Sci Rep (2017) 7 (1), 1698 DOI: 10.1038/s41598-017-01730-3
Rodrigues, Matafome, Sereno et al
Sci Rep (2017) 7 (1), 1698 DOI: 10.1038/s41598-017-01730-3
Cited by 56
AI Summary: In this study, OriGene's anti-Insulin Receptor (INSR) antibody (Cat# TA309063) was used to assess insulin receptor activation in adipose tissue, helping to demonstrate that glycation impairs insulin signaling and contributes to insulin resistance.
Insulin resistance is associated with tissue-specific regulation of HIF-1α and HIF-2α during mild chronic intermittent hypoxia
Sacramento, Ribeiro, Rodrigues et al
Respir Physiol Neurobiol (2016) 228, 30-8 DOI: 10.1016/j.resp.2016.03.007
Sacramento, Ribeiro, Rodrigues et al
Respir Physiol Neurobiol (2016) 228, 30-8 DOI: 10.1016/j.resp.2016.03.007
Cited by 68
AI Summary: In this study, OriGene products—including anti-HIF-1α (TA500381) and anti-HIF-2α (TA800872) antibodies—were used to assess tissue-specific changes in HIF-1α and HIF-2α protein expression during chronic intermittent hypoxia-induced insulin resistance.
K63 linked ubiquitin chain formation is a signal for HIF1A degradation by Chaperone-Mediated Autophagy
Ferreira, Soares, Ramalho et al
Sci Rep (2015) 5, 10210 DOI: 10.1038/srep10210
Ferreira, Soares, Ramalho et al
Sci Rep (2015) 5, 10210 DOI: 10.1038/srep10210
Cited by 99
AI Summary: OriGene products, specifically the HIF1A cDNA clone (Cat# SC119516) and HIF1A shRNA plasmid (Cat# TL312590), were used in this study to manipulate HIF1A expression and investigate its degradation via chaperone-mediated autophagy.
Showing 1-3 of 3 papers.
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