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GJA1 Goat Polyclonal Antibody

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SKU
AB0016-200
Goat Polyclonal Anti-CX43 Antibody
Size:
800 ug 2 mg
Conjugation:
Unconjugated
  $485.00
In Stock*
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View other "GJA1 or NM_000165" antibodies

Specifications
Specifications
Product Data
Application IF, WB
Recommended Dilution WB 1:500-1:2,000; IF 1:50-1:250; IHC (paraffin) 1:250-1:800; IHC (frozen) 1:250-1:800
Reactivity Canine, Human, Monkey, Mouse, Rat
Antibody Host Goat
Isotype IgG
Clonality Polyclonal
Immunogen Purified recombinant peptide derived from within residues 230 aa to the C-terminus of rat CX43 produced in E. coli.
Specificity Detects endogenous levels of total Connexin 43.
Buffer Polyclonal antibody supplied as a 200 µl (4 mg/ml) aliquot in PBS, 20% glycerol and 0.05% sodium azide. This antibody is epitope-affinity purified from goat antiserum and it is identical to AB1600-200.
Concentration 4mg/ml
Purification epitope affinity purified
Conjugation Unconjugated
Shipping Blue Ice
Gene Name gap junction protein alpha 1
Database Link
Background Gap junction protein, alpha 1, 43kDa
Synonyms Connexin-43; CX43; DFNB38; GJAL; HSS; ODD; ODDD; ODOD; SDTY3
Note Detects endogenous levels of total connexin 43.
Reference Data
Protein Categories Growth Factors, Membrane Proteins
Protein Families Druggable Genome, Ion Channels: Other, Transmembrane
Protein Pathways Arrhythmogenic right ventricular cardiomyopathy (ARVC), Gap junction
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Documents
Resources

file-alt Citations

Dysregulation of lncRNA-CCRR contributes to brain metastasis of breast cancer by intercellular coupling via regulating connexin 43 expression
Li, Li, Chen et al
J Cell Mol Med (2021)
Cited by 13
AI Summary: OriGene’s anti-CX43 antibody was used for Western blot analysis to assess CX43 protein expression, helping to demonstrate the regulatory relationship between lncRNA-CCRR and CX43 in breast cancer brain metastasis.
Snippet: In the next step, non- specific binding was blocked with Tris- buffered saline with Tween- 20 + 5% non- fat milk before the membrane was probed overnight at 4°C with primary anti- CX43 antibody (dilution 1:1000, OriGene Technologies) following the standard incubation
WB IHC
Presence of Cx43 in extracellular vesicles reduces the cardiotoxicity of the anti-tumour therapeutic approach with doxorubicin
Martins-Marques, Pinho, Zuzarte et al
J Extracell Vesicles (2016) 5, 32538 DOI: 10.3402/jev.v5.32538
Cited by 97
AI Summary: In this study, OriGene products including the human connexin43 (Cx43) expression plasmid (RC208307) and Cx43-specific antibody (TA500648) were used to manipulate and detect Cx43 in extracellular vesicles, enabling the authors to demonstrate that Cx43 presence reduces doxorubicin-induced cardiotoxicity without compromising anti-tumor efficacy.
FigureFigureFigure
Interacting Network of the Gap Junction (GJ) Protein Connexin43 (Cx43) is Modulated by Ischemia and Reperfusion in the Heart
Martins-Marques, Anjo, Pereira et al
Mol Cell Proteomics (2015) 14 (11), 3040-55 DOI: 10.1074/mcp.M115.052894
AI Summary: In this study, OriGene products—including the anti-Cx43 antibody (Cat# TA500648) and Cx43 expression plasmid (Cat# RC211307)—were used to detect and manipulate Connexin43 protein levels, enabling the analysis of its interacting network in rat hearts under ischemic and reperfusion conditions.
AMSH-mediated deubiquitination of Cx43 regulates internalization and degradation of gap junctions
Ribeiro-Rodrigues, Catarino, Marques et al
FASEB J (2014) 28 (11), 4629-41 DOI: 10.1096/fj.13-248963
Cited by 43
AI Summary: OriGene products, specifically the Cx43 expression plasmid (RC204307) and AMSH expression plasmid (RC210195), were used in this study to investigate how AMSH-mediated deubiquitination of Cx43 regulates the internalization and degradation of gap junctions.
Showing 1-4 of 4 papers.
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