LOX or lysyl oxidase is also known as protein-lysine 6-oxidase, a human protein encoded by the LOX gene. The inhibition of LOX can cause osteolathyrism. When LOX is upregulated by tumor cells, it may promote metastasis of the existing tumor that cause it to become malignant and cancerous.
|SKU#||TP313323 (20 ug)|
|Name||Recombinant protein of human lysyl oxidase (LOX)|
|Expression Host||HEK293 cells|
|Cited||In-vitro and in-vivo functional|
Human LOX from HEK293 cells
LOX purified from HEK293 cells shows high purity and protein activity. Activity data is cited from Cell Rep 2017.
An increased number of metastatic cells was found in the lungs of mice injected with OriGene recombinant LOX protein (SKU# TP313323) compared to control mice injected with PBS. Figure cited from Cell Rep 2017
Knocking down of LOX protein caused a reduction in the number of viable cells., which can be rescued by OriGene LOX protein (SKU# TP313323). Figure cited from EMBO Mol Med 2015
Citations for the recombinant LOX protein (TP313323)
- Cell Rep 2017, PubMed ID 28445728
- J. Biol. Chem. Nov 2015 ,PubMed ID 26601954
- Nature 2015 ,PubMed ID 26017313
- Cells Tissues Organs (Print) 2015 ,PubMed ID 25924936
- Cancer Res. 2013, PubMed ID 23188504
Other Cancer Research proteins
Full length human recombinant proteins made in human cell lines.
|Bcl x (BCL2L1)||TP301314|
|Ephrin B1 (EFNB1)||TP301886|
|Leukemia Inhibitory Factor (LIF)||TP310818|
|PDGF AA (PDGFA)||TP314164|
|TGF Beta1 (TGFB1)||TP300973|