Human Osteopontin (SPP1) activation kit by CRISPRa

SKU GA104596

SPP1 CRISPRa kit - CRISPR gene activation of human secreted phosphoprotein 1

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: SPP1
• Locus ID: 6696
• Components:

  GA104596G1, Osteopontin gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA104596G2, Osteopontin gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA104596G3, Osteopontin gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_000582, NM_001040058, NM_001040060, NM_001251829, NM_001251830
• UniProt ID: P10451
• Synonyms: BNSP; BSPI; ETA-1; OPN
• Summary: The protein encoded by this gene is involved in the attachment of osteoclasts to the mineralized bone matrix. The encoded protein is secreted and binds hydroxyapatite with high affinity. The osteoclast vitronectin receptor is found in the cell membrane and may be involved in the binding to this protein. This protein is also a cytokine that upregulates expression of interferon-gamma and interleukin-12. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]