Human IGF1 Receptor (IGF1R) activation kit by CRISPRa

SKU GA102349

IGF1R CRISPRa kit - CRISPR gene activation of human insulin like growth factor 1 receptor

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: IGF1R
• Locus ID: 3480
• Components:

  GA102349G1, IGF1 Receptor gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102349G2, IGF1 Receptor gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102349G3, IGF1 Receptor gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_000875, NM_001291858
• UniProt ID: P08069
• Synonyms: CD221; IGFIR; IGFR; JTK13
• Summary: This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014]