Estrogen Receptor 1 (ESR1) (NM_000125) Human Recombinant Protein
$867.00
In Stock*
Specifications
| Product Data | |
| Species | Human |
|---|---|
| Expression Host | HEK293T |
| Expression cDNA Clone or AA Sequence | |
| Tag | C-Myc/DDK |
| Predicted MW | 66 kDa |
| Concentration | >0.1 µg/µL as determined by microplate BCA method |
| Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
| Buffer | 25 mM Tris-HCl, 100 mM glycine, pH 7.3, 10% glycerol |
| Bioactivity | Binding assay (PMID: 28842010) |
| Preparation | Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. |
| Note | For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process. |
| Storage | Store at -80°C. |
| Stability | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
| Shipping | Dry Ice |
| Reference Data | |
| RefSeq | NP_000116 |
| Locus ID | 2099 |
| UniProt ID | P03372 |
| Cytogenetics | 6q25.1-q25.2 |
| RefSeq Size | 6456 |
| RefSeq ORF | 1785 |
| Synonyms | ER; Era; ESR; ESRA; ESTRR; NR3A1 |
| Summary | This gene encodes an estrogen receptor and ligand-activated transcription factor. The canonical protein contains an N-terminal ligand-independent transactivation domain, a central DNA binding domain, a hinge domain, and a C-terminal ligand-dependent transactivation domain. The protein localizes to the nucleus where it may form either a homodimer or a heterodimer with estrogen receptor 2. The protein encoded by this gene regulates the transcription of many estrogen-inducible genes that play a role in growth, metabolism, sexual development, gestation, and other reproductive functions and is expressed in many non-reproductive tissues. The receptor encoded by this gene plays a key role in breast cancer, endometrial cancer, and osteoporosis. This gene is reported to have dozens of transcript variants due to the use of alternate promoters and alternative splicing, however, the full-length nature of many of these variants remain uncertain. [provided by RefSeq, Jul 2020] |
| Protein Families | Druggable Genome, Nuclear Hormone Receptor, Transcription Factors |
Reviews
Documents
| FAQs |
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Resources
| Recombinant Protein Resources |
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|---|---|---|---|---|
| PH313277 | ESR1 MS Standard C13 and N15-labeled recombinant protein (NP_000116) | 10 ug |
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| PH326003 | ESR1 MS Standard C13 and N15-labeled recombinant protein (NP_001116212) | 10 ug |
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| PH326004 | ESR1 MS Standard C13 and N15-labeled recombinant protein (NP_001116213) | 10 ug |
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| LC400046 | ESR1 HEK293T cell transient overexpression lysate (as WB positive control) | 20 ug |
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| LC426553 | ESR1 HEK293T cell transient overexpression lysate (as WB positive control) | 20 ug |
$134.00
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|
| LC426554 | ESR1 HEK293T cell transient overexpression lysate (as WB positive control) | 20 ug |
$134.00
|
|
| LC426555 | ESR1 HEK293T cell transient overexpression lysate (as WB positive control) | 20 ug |
$134.00
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|
| LY400046 | Transient overexpression lysate of estrogen receptor 1 (ESR1), transcript variant 1 | 100 ug |
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|
| LY426553 | Transient overexpression lysate of estrogen receptor 1 (ESR1), transcript variant 2 | 100 ug |
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|
| LY426554 | Transient overexpression lysate of estrogen receptor 1 (ESR1), transcript variant 3 | 100 ug |
$436.00
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|
| LY426555 | Transient overexpression lysate of estrogen receptor 1 (ESR1), transcript variant 4 | 100 ug |
$436.00
|
|
| TP326003 | Purified recombinant protein of Homo sapiens estrogen receptor 1 (ESR1), transcript variant 2, 20 µg | 20 ug |
$867.00
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|
| TP326004 | Purified recombinant protein of Homo sapiens estrogen receptor 1 (ESR1), transcript variant 3, 20 µg | 20 ug |
$867.00
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|
| TP720514 | Recombinant protein of human estrogen receptor 1 (ESR1), transcript variant 1 | 10 ug |
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Citations
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.