Human NRAMP1 (SLC11A1) activation kit by CRISPRa

SKU GA104476

SLC11A1 CRISPRa kit - CRISPR gene activation of human solute carrier family 11 member 1

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: SLC11A1
• Locus ID: 6556
• Components:

  GA104476G1, NRAMP1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA104476G2, NRAMP1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA104476G3, NRAMP1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_000578, NM_001032220
• UniProt ID: P49279
• Synonyms: LSH; NRAMP; NRAMP1
• Summary: This gene is a member of the solute carrier family 11 (proton-coupled divalent metal ion transporters) family and encodes a multi-pass membrane protein. The protein functions as a divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Mutations in this gene have been associated with susceptibility to infectious diseases such as tuberculosis and leprosy, and inflammatory diseases such as rheumatoid arthritis and Crohn disease. Alternatively spliced variants that encode different protein isoforms have been described but the full-length nature of only one has been determined. [provided by RefSeq, Jul 2008]