IDH1/IDH2 Mutants & Gliomas
Authentic Reagents for the Research of Brain Tumors
OriGene offers cDNA clones and recombinant proteins of disease mutants and variants for the studies of brain tumors, such as IDH1 and IDH2. The bioactivities of IDH1 wild type, mutant and heterodimer have been tested in functional assays.
Enzymatic activities were determined by monitoring NADPH formation based on the absorbance at 345nm. The reaction was carried out at 37°C for 10 minutes in the presence of isocitrate as a substrate and NADP as a cofactor.
| Protein | Mutation | Affected NT# | Description | Effect | ORF clone SKU | SKU | Expression Host |
|---|---|---|---|---|---|---|---|
| IDH1 | Wild Type | N/A | N/A | N/A | HEK293 Sf9 Sf9 |
||
| R132H | c.395 | G to A | missense | HEK293 | |||
| WT/R132H | c.395 | G to A | Heterodimer | N/A | Sf9 | ||
| R132C | c.394 | C to T | missense | HEK293 Sf9 |
|||
| WT/R132C | c.394 | C to T | Heterodimer | N/A | Sf9 | ||
| R132L | c. 395 | G to T | missense | HEK293 Sf9 |
|||
| WT/R132L | c.395 | G to T | Heterodimer | N/A | Sf9 | ||
| R132S | c. 394 | C to A | missense | HEK293 Sf9 |
|||
| WT/R132S | c.394 | C to A | Heterodimer | N/A | Sf9 | ||
| R132G | c. 394 | C to G | missense | HEK293 Sf9 |
|||
| WT/R132G | c.394 | C to G | Heterodimer | N/A | Sf9 |
Human Brain Cancer Tissues
TissueFocus™ Individual Products
OriGene collected over 140,000 human tissue samples from U.S. medical centers using the industry's most strict ethical requirements and IRB protocols. The diagnosis of every tissue sample, whether cancer, normal or other disease, has been verified by an independent board-certified pathologist.
Product Types of Normal or Brain Cancer
- Tissue sections (FFPE or Frozen)
- Protein Lysates
- DNA
- RNA
Types of Diagnosis Covered
- Normal
- Astrocytoma
- Glioblastoma
- Gliosis
- Hemangiopericytoma
- Meningioma
- Oligoastrocytoma
- Oligodendroglioma
- Vascular malformation of brain
TissueScan™ cDNA Arrays for Brain Cancer
qPCR gene expression results of hundreds of tissues in 2 hours
<tdrowspan="3" scope="row">Human Brain
cDNA Array </tdrowspan="3">
| Array Name | Description | Clinical Info | QC Data | SKU | Size | Price |
|---|---|---|---|---|---|---|
| Brain Cancer cDNA Array I |
48 samples covering brain cancer four stages and normal tissues | Available | Available | 2 plates | $850 | |
| 5 plates | $1500 | |||||
| 10 plates | $2000 | |||||
| 24 samples covering all major human brain normal tissues at different locations | N/A | Available | 2 plates | $480 | ||
| 5 plates | $900 | |||||
| 10 plates | $1500 |