IDH1/IDH2 Mutants & Gliomas

Authentic Reagents for the Research of Brain Tumors

OriGene offers cDNA clones and recombinant proteins of disease mutants and variants for the studies of brain tumors, such as IDH1 and IDH2. The bioactivities of IDH1 wild type, mutant and heterodimer have been tested in functional assays.

Enzymatic activities were determined by monitoring NADPH formation based on the absorbance at 345nm. The reaction was carried out at 37°C for 10 minutes in the presence of isocitrate as a substrate and NADP as a cofactor.

IDH1 proteins
Protein Mutation Affected NT# Description Effect ORF clone SKU SKU Expression Host
IDH1 Wild Type N/A N/A N/A RC210582 TP310582
R132H c.395 G to A missense RC400096 TP700038 HEK293
WT/R132H c.395 G to A Heterodimer N/A TP710048 Sf9
R132C c.394 C to T missense RC400097 TP700039
WT/R132C c.394 C to T Heterodimer N/A TP710049 Sf9
R132L c. 395 G to T missense RC400098 TP700040
WT/R132L c.395 G to T Heterodimer N/A TP710050 Sf9
R132S c. 394 C to A missense RC400099 TP700041
WT/R132S c.394 C to A Heterodimer N/A TP710051 Sf9
R132G c. 394 C to G missense RC400100 TP700042
WT/R132G c.394 C to G Heterodimer N/A TP710052 Sf9

Human Brain Cancer Tissues

TissueFocus™ Individual Products

OriGene collected over 140,000 human tissue samples from U.S. medical centers using the industry's most strict ethical requirements and IRB protocols. The diagnosis of every tissue sample, whether cancer, normal or other disease, has been verified by an independent board-certified pathologist.

Product Types of Normal or Brain Cancer
  • Tissue sections (FFPE or Frozen)
  • Protein Lysates
  • DNA
  • RNA
Types of Diagnosis Covered
  • Normal
  • Astrocytoma
  • Glioblastoma
  • Gliosis
  • Hemangiopericytoma
  • Meningioma
  • Oligoastrocytoma
  • Oligodendroglioma
  • Vascular malformation of brain

TissueScan™ cDNA Arrays for Brain Cancer

qPCR gene expression results of hundreds of tissues in 2 hours
TissueScan cDNA arrays
Array Name Description Clinical Info QC Data SKU Size Price
Brain Cancer
cDNA Array I
48 samples covering brain cancer four stages and normal tissues Available Available HBRT102 2 plates $850
HBRT302 5 plates $1500
HBRT502 10 plates $2000
Human Brain
cDNA Array
24 samples covering all major human brain normal tissues at different locations N/A Available HBRT101 2 plates $480
HBRT301 5 plates $900
HBRT501 10 plates $1500