M-CSF (CSF1) (NM_172212) Human Recombinant Protein

CAT#: TP723739

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Purified recombinant protein of Human colony stimulating factor 1 (macrophage) (CSF1), transcript variant 4


Product Datasheet for 'TP723739'


  View other "CSF1" proteins (20)

USD 170.00


Availability*
5 Days

Size
    • 10 ug


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Specifications

Product Data
Description Purified recombinant protein of Human colony stimulating factor 1 (macrophage) (CSF1), transcript variant 4
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence Human M-CSF, the region of Glu33-Ser190, from gene Accession# NM_172212.2
Tag Tag Free
Predicted MW 20.6 kDa
Concentration Protein formulated and vialed at >50 ug/mL in specified buffer
Purity >98%, as determined by Coomassie stained SDS-PAGE.
Buffer 1 x PBS
Bioactivity The ED50 is 0.5 - 2 ng/ml, corresponding to a specific activity of 0.5 - 2 x 10^6 units/mg, determined by M-NFS60 cell proliferation induced by human M-CSF in a dose dependent manner.
Endotoxin Less than 0.01 ng per µg protein as determined by the LAL method
Reference Data
RefSeq NP_757351
Locus ID 1435
Refseq Size 2772
Cytogenetics 1p13.3
Refseq ORF 1662
Synonyms CSF-1; MCSF
Summary The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of macrophages. The active form of the protein is found extracellularly as a disulfide-linked homodimer, and is thought to be produced by proteolytic cleavage of membrane-bound precursors. The encoded protein may be involved in development of the placenta. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011]
Protein Families Druggable Genome, ES Cell Differentiation/IPS, Secreted Protein, Transmembrane
Protein Pathways Cytokine-cytokine receptor interaction, Hematopoietic cell lineage

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