TrkB (NTRK2) (NM_006180) Human Recombinant Protein

CAT#: TP321794

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Recombinant protein of human neurotrophic tyrosine kinase, receptor, type 2 (NTRK2), transcript variant a


 Product Datasheet for 'TP321794'

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USD 748.00


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Size
    • 20 ug


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Specifications

Product Data
Description Recombinant protein of human neurotrophic tyrosine kinase, receptor, type 2 (NTRK2), transcript variant a
Species Human
Expression Host HEK293T
Tag C-Myc/DDK
Predicted MW 90.1 kDa
Concentration >50 ug/mL as determined by microplate BCA method
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Preparation Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
Reference Data
RefSeq NP_006171
Locus ID 4915
Refseq Size 5608
Cytogenetics 9q21.33
Refseq ORF 2514
Synonyms EIEE58; GP145-TrkB; OBHD; trk-B; TRKB
Summary This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation. Mutations in this gene have been associated with obesity and mood disorders. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
Protein Families Druggable Genome, Protein Kinase, Transmembrane
Protein Pathways MAPK signaling pathway, Neurotrophin signaling pathway

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