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LAPTM4B (NM_018407) Human Mass Spec Standard

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SKU
PH307325
LAPTM4B MS Standard C13 and N15-labeled recombinant protein (NP_060877)
Size:
10 ug
  $3,360.00
3 Weeks*
Bulk/Customize

Frequently Bought Together (2)

TA342374 Rabbit Polyclonal Anti-LAPTM4B Antibody
100 ul
$585.00
LY413079 Transient overexpression lysate of lysosomal protein transmembrane 4 beta (LAPTM4B) (as WB positive control) 100 ug
$436.00

Other products for "LAPTM4B or NM_018407"

Specifications
Specifications
Product Data
Tag C-Myc/DDK
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence RC207325
Predicted MW 35 kDa
Protein Sequence
Protein Sequence
>RC207325 protein sequence
Red=Cloning site Green=Tags(s)

MTSRTRVTWPSPPRPLPVPAAAAVAFGAKGTDPAEARSSRGIEEAGPRAHGRAGREPERRRSRQQRRGGL
QARRSTLLKTCARASATAPGAMKMVAPWTRFYSNSCCLCCHVRTGTILLGVWYLIINAVVLLILLSALAD
PDQYNFSSSELGGDFEFMDDANMCIAIAISLLMILICATATYGAYKQRAAWIIPFFCYQIFDFALNMLVA
ITVLIYPNSIQEYIRQLPPNFPYRDDVMSVNPTCLVLIILLFISIILTFKGYLISCVWNCYRYINGRNSS
DVLVYVTSNDTTVLLPPYDDATVNGAAKEPPPPYVSA

TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration >0.05 µg/µL as determined by microplate BCA method
Labeling Method Labeled with U- 13C6, 15N4-L-Arginine and U- 13C6, 15N2-L-Lysine
Buffer 25 mM Tris-HCl, 100 mM glycine, pH 7.3
Storage Store at -80°C. Avoid repeated freeze-thaw cycles.
Stability Stable for 3 months from receipt of products under proper storage and handling conditions.
Shipping Dry Ice
Reference Data
RefSeq NP_060877
RefSeq Size 2242
RefSeq ORF 951
Synonyms LAPTM4beta; LC27
Locus ID 55353
UniProt ID Q86VI4
Cytogenetics 8q22.1
Summary Required for optimal lysosomal function (PubMed:21224396). Blocks EGF-stimulated EGFR intraluminal sorting and degradation. Conversely by binding with the phosphatidylinositol 4,5-bisphosphate, regulates its PIP5K1C interaction, inhibits HGS ubiquitination and relieves LAPTM4B inhibition of EGFR degradation (PubMed:25588945). Recruits SLC3A2 and SLC7A5 (the Leu transporter) to the lysosome, promoting entry of leucine and other essential amino acid (EAA) into the lysosome, stimulating activation of proton-transporting vacuolar (V)-ATPase protein pump (V-ATPase) and hence mTORC1 activation (PubMed:25998567). Plays a role as negative regulator of TGFB1 production in regulatory T cells (PubMed:26126825). Binds ceramide and facilitates its exit from late endosome in order to control cell death pathways (PubMed:26280656).UniProtKB/Swiss-Prot Function
Protein Families Transmembrane
Protein Pathways Lysosome
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Other "LAPTM4B" proteins (3)
SKU Description Size Price
LC413079 Lyophilized LAPTM4B HEK293T cell transient overexpression lysate (as WB positive control) 20 ug
$206.00
LY413079 Transient overexpression lysate of lysosomal protein transmembrane 4 beta (LAPTM4B) (as WB positive control) 100 ug
$436.00
TP307325 Recombinant protein of human lysosomal protein transmembrane 4 beta (LAPTM4B), 20 µg 20 ug
$867.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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