PKM2 (PKM) Human Gene Knockout Kit (CRISPR)
CAT#: KN201855BN
PKM - human gene knockout kit via CRISPR, HDR mediated
Functional Cassette: GFP-puro Luciferase-Puro RFP-BSD
HDR-mediated knockout kit validation
USD 1,657.00
4 Weeks*
Specifications
Product Data | |
Format | 2 gRNA vectors, 1 mBFP-Neo donor, 1 scramble control |
Donor DNA | mBFP-Neo |
Symbol | PKM2 |
Locus ID | 5315 |
Components |
KN201855G1, PKM2 gRNA vector 1 in pCas-Guide CRISPR vector KN201855G2, PKM2 gRNA vector 2 in pCas-Guide CRISPR vector KN201855BND, donor DNA containing left and right homologous arms and mBFP-Neo functional cassette. GE100003, scramble sequence in pCas-Guide vector |
Disclaimer | These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process. |
Reference Data | |
RefSeq | NM_001206796, NM_001206797, NM_001206798, NM_001206799, NM_001316318, NM_002654, NM_182470, NM_182471 |
UniProt ID | P14618 |
Synonyms | CTHBP; HEL-S-30; OIP3; PK3; PKM2; TCB; THBP1 |
Summary | This gene encodes a protein involved in glycolysis. The encoded protein is a pyruvate kinase that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate to ADP, generating ATP and pyruvate. This protein has been shown to interact with thyroid hormone and may mediate cellular metabolic effects induced by thyroid hormones. This protein has been found to bind Opa protein, a bacterial outer membrane protein involved in gonococcal adherence to and invasion of human cells, suggesting a role of this protein in bacterial pathogenesis. Several alternatively spliced transcript variants encoding a few distinct isoforms have been reported. [provided by RefSeq, May 2011] |
Documents
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Other Versions
SKU | Description | Size | Price |
---|---|---|---|
KN201855 | PKM - human gene knockout kit via CRISPR, HDR mediated |
USD 1,657.00 |
|
KN201855LP | PKM - human gene knockout kit via CRISPR, HDR mediated |
USD 1,657.00 |
|
KN201855RB | PKM - human gene knockout kit via CRISPR, HDR mediated |
USD 1,657.00 |
|
KN401855 | PKM - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. |
USD 1,657.00 |
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GA103576 | PKM CRISPRa kit - CRISPR gene activation of human pyruvate kinase M1/2 |
USD 1,657.00 |
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