Human Smek1 (PPP4R3A) activation kit by CRISPRa

SKU GA110873

PPP4R3A CRISPRa kit - CRISPR gene activation of human protein phosphatase 4 regulatory subunit 3A

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: PPP4R3A
• Locus ID: 55671
• Components:

  GA110873G1, Smek1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA110873G2, Smek1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA110873G3, Smek1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_001284280, NM_001284281, NM_017936, NM_032560, NR_158976, NM_001366432
• UniProt ID: Q6IN85
• Synonyms: FLFL1; KIAA2010; MSTP033; PP4R3; PP4R3A; SMEK1; smk-1; smk1
• Summary: Regulatory subunit of serine/threonine-protein phosphatase 4. May regulate the activity of PPP4C at centrosomal microtubule organizing centers. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on 'Ser-140' (gamma-H2AFX) generated during DNA replication and required for DNA DSB repair.[UniProtKB/Swiss-Prot Function]