Human NSMase2 (SMPD3) activation kit by CRISPRa

SKU GA110771

SMPD3 CRISPRa kit - CRISPR gene activation of human sphingomyelin phosphodiesterase 3

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: SMPD3
• Locus ID: 55512
• Components:

  GA110771G1, NSMase2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA110771G2, NSMase2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA110771G3, NSMase2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_018667
• UniProt ID: Q9NY59
• Synonyms: NSMASE2
• Summary: Catalyzes the hydrolysis of sphingomyelin to form ceramide and phosphocholine. Ceramide mediates numerous cellular functions, such as apoptosis and growth arrest, and is capable of regulating these 2 cellular events independently. Also hydrolyzes sphingosylphosphocholine. Regulates the cell cycle by acting as a growth suppressor in confluent cells. Probably acts as a regulator of postnatal development and participates in bone and dentin mineralization.[UniProtKB/Swiss-Prot Function]