Human NADPH oxidase 4 (NOX4) activation kit by CRISPRa

SKU GA109420

NOX4 CRISPRa kit - CRISPR gene activation of human NADPH oxidase 4

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: NOX4
• Locus ID: 50507
• Components:

  GA109420G1, NADPH oxidase 4 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA109420G2, NADPH oxidase 4 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA109420G3, NADPH oxidase 4 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_001143836, NM_001143837, NM_001291926, NM_001291927, NM_001291929, NM_001300995, NM_016931, NR_026571, NR_120406
• UniProt ID: Q9NPH5
• Synonyms: KOX; KOX-1; RENOX
• Summary: This gene encodes a member of the NOX-family of enzymes that functions as the catalytic subunit the NADPH oxidase complex. The encoded protein is localized to non-phagocytic cells where it acts as an oxygen sensor and catalyzes the reduction of molecular oxygen to various reactive oxygen species (ROS). The ROS generated by this protein have been implicated in numerous biological functions including signal transduction, cell differentiation and tumor cell growth. A pseudogene has been identified on the other arm of chromosome 11. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jan 2009]