Human Acid sphingomyelinase (SMPD1) activation kit by CRISPRa

SKU GA104522

SMPD1 CRISPRa kit - CRISPR gene activation of human sphingomyelin phosphodiesterase 1

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: SMPD1
• Locus ID: 6609
• Components:

  GA104522G1, Acid sphingomyelinase gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA104522G2, Acid sphingomyelinase gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA104522G3, Acid sphingomyelinase gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_000543, NM_001007593, NM_001318087, NM_001318088, NR_027400, NR_134502, NM_001365135
• UniProt ID: P17405
• Synonyms: ASM; ASMASE; NPD
• Summary: The protein encoded by this gene is a lysosomal acid sphingomyelinase that converts sphingomyelin to ceramide. The encoded protein also has phospholipase C activity. Defects in this gene are a cause of Niemann-Pick disease type A (NPA) and Niemann-Pick disease type B (NPB). Multiple transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2010]